Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 23, Pages 25676-25682Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c07356
Keywords
MOFs; pulmonary delivery; microencapsulation; mannitol; MIL-100 nanoparticles
Funding
- Xunta de Galicia [ED431C 2017/09-FEDER]
- regional Madrid founding (Talento 2017 Modality 2) [2017-T2/IND-5149]
- Multifunctional Metallodrugs in Diagnosis and Therapy Network (MICIU) [RED2018-102471-T]
- Spanish Ramon y Cajal Programme [2014-16823]
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Although nanoscaled metal-organic frameworks (nanoMOFs) are promising drug carriers, their appropriate formulation remains almost unexplored and basically restricted to intravenous routes. Lungs, beneficiating from a large absorption surface and low enzymatic presence, are a very attractive target for both local and systemic delivery. However, pulmonary nanoMOF formulation is a pending and defying task. Thus, we propose a pioneer nanoMOF-based microsphere system as a potential platform for pulmonary administration. A biocompatible nanoMOF was successfully encapsulated in mannitol by a simple and continuous spray-drying technique. Upon intratracheal administration to rats, the resulting formulation, exhibiting optimal properties (i.e., homogeneity, size, density, and spray-drying process yield), was able to release the intact nanoMOF carrier uniformly along the lungs, reaching the bronchioles and alveoli.
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