Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 20, Pages 22534-22542Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c03523
Keywords
large-wound self-healing; temperature sensitivity; host-guest assembly; biocompatibility; intrinsic self-healing
Funding
- National Natural Science Foundation of China (NSFC) [21506038, 51773229]
- Natural Science Foundation of Guangdong Province [2014A030310307]
- China Postdoctoral Science Foundation [2015T80897]
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Implantable and wearable materials, which are usually used in/on a biological body, are mostly needed with biomimetic self-healing function. To enable repeatable large-wound self-healing and volume/structure recovery, we verified a proof-of-concept approach in this work. We design a polymer hydrogel that combines temperature responsiveness with an intrinsic self-healing ability through host-guest orthogonal self-assembly between two types of poly(N-isopropylacrylamide) (PNIPAM) oligomers. The result is thermosensitive, capable of fast self-repair of microcracks based on reversible host-guest assembly. More importantly, when a large open wound appears, the hydrogel can first close the wound via volume swelling and then completely self-repair the damage in terms of intrinsic self-healing. Meanwhile, its original volume can be easily recovered by subsequent contraction. As demonstrated by the experimental data, such millimeter-level wound self-healing and volume recovery can be repeatedly carried out in response to the short-term cooling stimulus. With low cytotoxicity and good biocompatibility, moreover, this highly intelligent hydrogel is greatly promising for practical large-wound self-healing in wound dressing, electronic skins, wearable biosensors, and humanoid robotics, which can tolerate large-scale human motions.
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