Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 20, Pages 22479-22491Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c01967
Keywords
photodynamic therapy; CO gas therapy; antibacterial; ablation of biofilms; CORM-401
Funding
- National Natural Science Foundation of China [51503131, 51703245]
- Natural Science Foundation of Jiangsu Province [BK20181377, BK20170733]
- Hangzhou Medical and Health Science and Technology Project [OO20190807]
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In recent years, with the emergence of various kinds of drug-resistant bacteria, existing antibiotics have become inefficient in killing these bacteria, and the formation of biofilms has further weakened the therapeutic effect. More problematically, the massive use and abuse of antibiotics have caused severe side effects. Thus, the development of ultra- efficient and safe antibacterial systems is urgently needed. Herein, a photodynamic therapy (PDT)-driven CO-controlled delivery system (Ce6&CO@ FADP) is developed for synergistic antibacterial and ablation biofilms. Ce6&CO@FADP is constructed using a fluorinated amphiphilic dendritic peptide (FADP) and physically loaded with Ce6 and CORM-401. After efficiently entering the bacteria, Ce6&CO@FADP can rapidly release CO intracellularly by the massive consumption of the H2O2 generated during the PDT process, without affecting the generation of singlet oxygen (O-1(2)). As such, the combination of CO and O-1(2) exerts notable synergistic antibacterial and biofilm ablation effects both in vitro and in vivo (including subcutaneous bacterial infection and biofilm catheter models) experiments. More importantly, all biosafety assessments suggest the good biocompatibility of Ce6&CO@FADP. Together, these results reveal that Ce6&CO@FADP is an efficient and safe antibacterial system, which has essential application prospects for the treatment of bacterial infections and ablation of biofilms in vivo.
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