Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 15, Pages 17969-17978Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c00646
Keywords
wood; scaffolds; anisotropy; liquid transport; cell migration and alignment
Funding
- National Natural Science Foundation of China [51903170, 51925304, 51803133]
- China Postdoctoral Science Foundation [2019M653399]
- Postdoctoral Interdisciplinary Innovation Foundation of Sichuan University
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Fantastic structures in nature have inspired much incredible research. Wood, a typical model of anisotropy and hierarchy, has been widely investigated for its mechanical properties and water extraction abilities, although applications in biological areas remain challenging. Delignified wood composite with in situ deposited hydroxyapatite (HAp) and infiltrated polycaprolactone (PCL) is hereby fabricated in an attempt to mimic natural bone. The inherent structure and properties of wood are carefully preserved during the fabrication, showing anisotropic mechanical properties in the radial direction (420 MPa) and longitudinal direction (20 MPa). In addition, it also performs directional liquid transport, effectively inducing the migration and alignment of cells to simulate the uniform seeding behavior of various cells in natural bone. Moreover, the synergistic effect of blended HAp and PCL largely promotes cell proliferation and osteogenic differentiation, providing a promising candidate for bone regeneration materials.
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