Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 14, Pages 16050-16057Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c00497
Keywords
tissue adhesion; wound dressing; biodegradable polymer; rheology; viscoelasticity
Funding
- Maryland NanoCenter
- AIMLab
- Functional Macromolecular Laboratory
- Sheikh Zayed Institute for Pediatric Surgical Innovation
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [R01EB019963, F31EB025735]
- UMD ASPIRE program
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Viscoelastic blends of biodegradable polyesters with low and high molecular weight distributions have remarkably strong adhesion (significantly greater than 1 N/cm(2)) to soft, wet tissue. Those that transition from viscous flow to elastic, solidlike behavior at approximately 1 Hz demonstrate pressure-sensitivity yet also have sufficient elasticity for durable bonding to soft, wet tissue. The pressure-sensitive tissue adhesive (PSTA) blends produce increasingly stronger pull-apart adhesion in response to compressive pressure application, from 10 to 300 s. By incorporating a stiffer high molecular weight component, the PSTA exhibits dramatically improved burst pressure (greater than 100 kPa) when used as a tissue sealant. The PSTA's biodegradation mechanism can be switched from erosion (occurring primarily over the first 10 days) to bulk chemical degradation (and minimal erosion) depending on the chemistry of the high molecular weight component. Interestingly, fibrosis toward the PSTA is reduced when fast-occurring erosion is the dominant biodegradation mechanism.
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