Hybrid Graphene/Conducting Polymer Strip Sensors for Sensitive and Selective Electrochemical Detection of Serotonin

There is an urgent need for electrochemical sensor materials that exhibit electrochemically compliant properties while also retaining high durability under physiological conditions. Herein, we demonstrate a novel strip-style electrochemical sensor using reduced graphene oxide (rGO) and poly(ethylene dioxythiophene)/poly(styrene sulfonic acid) (PEDOT/PSS) nanocomposite films. The fabricated rGO-PEDOT/PSS sensor with and without nafion has shown an effective electrochemical response for both selectivity and sensitivity of the serotonin (5-hydroxytryptamine, 5-HT) neurotransmitter. The developed high-performance hybrid graphene/conducting polymer strip sensors are likely to find applications as chip electrochemical sensor devices for patients diagnosed with Alzheimer's disease.