Journal
BRAIN SCIENCES
Volume 10, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/brainsci10020126
Keywords
probiotics; Streptococcus thermophilus; ST285; MBP83-99 peptide; mannan; immune modulation; multiple sclerosis; agonist peptide
Categories
Funding
- Immunology and Translational Research Group
- Mechanisms and Interventions in Health and Disease Program
- Institute of Health and Sport, Victoria University, Australia
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Probiotic bacteria have beneficial effects to the development and maintenance of a healthy microflora that subsequently has health benefits to humans. Some of the health benefits attributed to probiotics have been noted to be via their immune modulatory properties suppressing inflammatory conditions. Hence, probiotics have become prominent in recent years of investigation with regard to their health benefits. As such, in the current study, we determined the effects of Streptococcus thermophilus to agonist MBP83-99 peptide immunized mouse spleen cells. It was noted that Streptococcus thermophilus induced a significant increase in the expression of anti-inflammatory IL-4, IL-5, IL-10 cytokines, and decreased the secretion of pro-inflammatory IL-1 beta and IFN-gamma. Regular consumption of Streptococcus thermophilus may therefore be beneficial in the management and treatment of autoimmune diseases such as multiple sclerosis.
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