Journal
ANNALS OF TRANSLATIONAL MEDICINE
Volume 7, Issue 23, Pages -Publisher
AME PUBL CO
DOI: 10.21037/atm.2019.11.116
Keywords
Single-cell sequencing; hepatocellular carcinoma (HCC); heterogeneity
Categories
Funding
- Beijing Natural Science Foundation [L172055]
- Beijing Municipal Science & Technology Commission research fund [Z171100000417004]
- WBE Liver Fibrosis Foundation [CFHPC 2020021]
- Beijing Dongcheng District outstanding talent funding project
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Single-cell sequencing technology refers to the sequencing of the genome, transcriptome and epigenome in one single cell. Comparing to traditional histology, single-cell sequencing can reveal the genetic heterogeneity among different cells. Due to the complex pathogenesis and various pathological types of hepatocellular carcinoma (HCC), studies on the heterogeneity of tumor cells confer improvement for its clinical diagnosis, treatment and prognosis. This article summarizes the principal basis and development of single-cell sequencing technology, as well as its increasing application in the field of HCC.
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