Journal
MICROORGANISMS
Volume 7, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms7120691
Keywords
gut microbiota; vascular inflammation; arterial thrombosis; cardiovascular disease; blood pressure regulation
Categories
Funding
- CTH [TRP X27, X30 (BMBF 01EO1503)]
- Boehringer Ingelheim Foundation
- Naturwissenschaftlich-Medizinischs Forschungszentrum (NMFZ)
- EMBO Short Term Fellowship [7605]
- Inneruniversitare Forschungsforderung, Johannes Gutenberg-University of Mainz
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The gut microbiota has emerged as a contributing factor in the development of atherosclerosis and arterial thrombosis. Metabolites from the gut microbiota, such as trimethylamine N-oxide and short chain fatty acids, were identified as messengers that induce cell type-specific signaling mechanisms and immune reactions in the host vasculature, impacting the development of cardiovascular diseases. In addition, microbial-associated molecular patterns drive atherogenesis and the microbiota was recently demonstrated to promote arterial thrombosis through Toll-like receptor signaling. Furthermore, by the use of germ-free mouse models, the presence of a gut microbiota was shown to influence the synthesis of endothelial adhesion molecules. Hence, the gut microbiota is increasingly being recognized as an influencing factor of arterial thrombosis and attempts of dietary pre- or probiotic modulation of the commensal microbiota, to reduce cardiovascular risk, are becoming increasingly significant.
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