4.7 Review

Autophagy Function and Regulation in Kidney Disease

Related references

Note: Only part of the references are listed.
Editorial Material Cell Biology

Podocytes and autophagy: a potential therapeutic target in lupus nephritis

Xu-Jie Zhou et al.

AUTOPHAGY (2019)

Article Multidisciplinary Sciences

Suppression of autophagic activity by Rubicon is a signature of aging

Shuhei Nakamura et al.

NATURE COMMUNICATIONS (2019)

Article Cell Biology

Disrupted apolipoprotein L1-miR193a axis dedifferentiates podocytes through autophagy blockade in an APOL1 risk milieu

Vinod Kumar et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2019)

Article Medicine, Research & Experimental

FoxO3 activation in hypoxic tubules prevents chronic kidney disease

Ling Li et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Pharmacology & Pharmacy

Atrasentan alleviates high glucose-induced podocyte injury by the microRNA-21/forkhead box O1 axis

Jie Wang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Biotechnology & Applied Microbiology

Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice

Hung-Cheng Tsai et al.

BIOMED RESEARCH INTERNATIONAL (2019)

Article Food Science & Technology

Role of TFEB in autophagic modulation of ischemia reperfusion injury in mice kidney and protection by urolithin A

Ying Wang et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Article Physiology

Autophagy in Kidney Disease

Mary E. Choi

Annual Review of Physiology (2019)

Article Biochemistry & Molecular Biology

Effect of Klotho on autophagy clearance in tacrolimus-induced renal injury

Sun Woo Lim et al.

FASEB JOURNAL (2019)

Article Medicine, Research & Experimental

Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis

Divya Bhatia et al.

JCI INSIGHT (2019)

Review Cell Biology

Periostin function in communication with extracellular matrices

Akira Kudo et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2018)

Article Biochemistry & Molecular Biology

Protein kinase C drives fibroblast activation and kidney fibrosis by stimulating autophagic flux

Xian Xue et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Cell Biology

TAK1 mediates excessive autophagy via p38 and ERK in cisplatin-induced acute kidney injury

Jun Zhou et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Article Endocrinology & Metabolism

MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy

Yingying Zhang et al.

JOURNAL OF DIABETES RESEARCH (2018)

Article Biochemistry & Molecular Biology

Activation of autophagy contributes to the renoprotective effect of postconditioning on acute kidney injury and renal fibrosis

Yaolin Song et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Physiology

SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy

Wenyu Zhao et al.

FRONTIERS IN PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential

Danyi Yang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Article Transplantation

Ursolic acid improves podocyte injury caused by high glucose

Li Xu et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2017)

Article Urology & Nephrology

Valproic acid attenuates renal fibrosis through the induction of autophagy

Koichiro Kawaoka et al.

CLINICAL AND EXPERIMENTAL NEPHROLOGY (2017)

Article Biochemistry & Molecular Biology

Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model

Ping Zhu et al.

HUMAN MOLECULAR GENETICS (2017)

Article Multidisciplinary Sciences

Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker's yeast fuel advances in biomedical research

Beth Levine et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Pharmacology & Pharmacy

Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes

Yingli Jin et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Forkhead box O3 (FoxO3) regulates kidney tubular autophagy following urinary tract obstruction

Ling Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Cardiac & Cardiovascular Systems

Suppression of autophagic flux contributes to cardiomyocyte death by activation of necroptotic pathways

Makoto Ogasawara et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2017)

Article Urology & Nephrology

Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes

Tamadher A. Alghamdi et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Article Medicine, Research & Experimental

Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells

Hyo-Jin Kim et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

Article Biochemistry & Molecular Biology

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

Pazit Beckerman et al.

NATURE MEDICINE (2017)

Review Biotechnology & Applied Microbiology

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Lorenzo Galluzzi et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Review Urology & Nephrology

Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases

Andrey V. Cybulsky

NATURE REVIEWS NEPHROLOGY (2017)

Article Chemistry, Multidisciplinary

Tailoring trehalose for biomedical and biotechnological applications

Mara K. O'Neill et al.

PURE AND APPLIED CHEMISTRY (2017)

Review Biochemistry & Molecular Biology

Emerging Mechanisms in Initiating and Terminating Autophagy

Manuela Antonioli et al.

TRENDS IN BIOCHEMICAL SCIENCES (2017)

Article Medicine, Research & Experimental

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

Xiao-yu Li et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2017)

Article Multidisciplinary Sciences

Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling

Yue Tu et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure

Tammo Mueller et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

Article Physiology

Autophagy is activated to protect against podocyte injury in adriamycin-induced nephropathy

Mixuan Yi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2017)

Review Biochemistry & Molecular Biology

Molecular definitions of autophagy and related processes

Lorenzo Galluzzi et al.

EMBO JOURNAL (2017)

Review Biochemistry & Molecular Biology

Initiation and execution mechanisms of necroptosis: an overview

Sasker Grootjans et al.

CELL DEATH AND DIFFERENTIATION (2017)

Review Biochemistry & Molecular Biology

mTORC1 senses stresses: Coupling stress to proteostasis

Kuo-Hui Su et al.

BIOESSAYS (2017)

Article Biochemistry & Molecular Biology

Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy via the AMPK/mTOR signaling pathway

Hui Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Correction Biochemistry & Molecular Biology

mTOR Signaling in Growth, Metabolism, and Disease (vol 168, pg 960, 2017)

Robert A. Saxton et al.

Review Cell Biology

mTORC1 signaling and the metabolic control of cell growth

Issam Ben-Sahra et al.

CURRENT OPINION IN CELL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Synergistic effect of apoptosis and necroptosis inhibitors in cisplatin-induced nephrotoxicity

Vivian Regina Tristao et al.

APOPTOSIS (2016)

Article Urology & Nephrology

Renal 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase Is an Important Determinant of AKI Severity after Ischemia-Reperfusion

Edwin K. Jackson et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Article Urology & Nephrology

Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease

Shoji Kuwahara et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Article Urology & Nephrology

Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments

Arpita Baisantry et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Article Cell Biology

Inhibition of BMI1 induces autophagy-mediated necroptosis

Anindya Dey et al.

AUTOPHAGY (2016)

Article Cell Biology

Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

Review Biochemistry & Molecular Biology

Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?

Yuan Ying et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Review Biochemistry & Molecular Biology

Regulated cell death and adaptive stress responses

Lorenzo Galluzzi et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Article Cell Biology

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

Megan L. Goodall et al.

DEVELOPMENTAL CELL (2016)

Article Biochemistry & Molecular Biology

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

Cindy Puente et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Urology & Nephrology

Autophagy in acute kidney injury

Gur P. Kaushal et al.

KIDNEY INTERNATIONAL (2016)

Review Urology & Nephrology

Autophagy and Tubular Cell Death in the Kidney

Andrea Havasi et al.

SEMINARS IN NEPHROLOGY (2016)

Review Urology & Nephrology

An Overview of Pathways of Regulated Necrosis in Acute Kidney Injury

Jesper Kers et al.

SEMINARS IN NEPHROLOGY (2016)

Article Pharmacology & Pharmacy

Role of necroptosis in autophagy signaling during hepatic ischemia and reperfusion

Jeong-Min Hong et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

Review Cell Biology

Digesting the Expanding Mechanisms of Autophagy

Nicholas T. Ktistakis et al.

TRENDS IN CELL BIOLOGY (2016)

Review Cell Biology

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

Aliaksandr Khaminets et al.

TRENDS IN CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

GADD34 Keeps the mTOR Pathway Inactivated in Endoplasmic Reticulum Stress Related Autophagy

Marianna Holczer et al.

PLOS ONE (2016)

Review Cell Biology

Autophagy: machinery and regulation

Zhangyuan Yin et al.

MICROBIAL CELL (2016)

Review Cell Biology

Transcriptional and epigenetic regulation of autophagy in aging

Louis R. Lapierre et al.

AUTOPHAGY (2015)

Article Biochemistry & Molecular Biology

Necroptosis mediated by receptor interaction protein kinase 1 and 3 aggravates chronic kidney injury of subtotal nephrectomised rats

Yongjun Zhu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Review Biochemistry & Molecular Biology

Recent insights into cell death and autophagy

Brent E. Fitzwalter et al.

FEBS JOURNAL (2015)

Review Medicine, Research & Experimental

Autophagy and neurodegeneration

Rebecca A. Frake et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Immunology

Amino Acid Metabolism Inhibits Antibody-Driven Kidney Injury by Inducing Autophagy

Kapil Chaudhary et al.

JOURNAL OF IMMUNOLOGY (2015)

Article Genetics & Heredity

mTOR in health and in sickness

Dritan Liko et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2015)

Article Urology & Nephrology

A Role for Tubular Necroptosis in Cisplatin-Induced AKI

Yanfang Xu et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

Review Urology & Nephrology

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

Manjeri A. Venkatachalam et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

Article Biochemistry & Molecular Biology

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Daniel F. Egan et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity

F. M. Menzies et al.

CELL DEATH AND DIFFERENTIATION (2015)

Article Urology & Nephrology

Disruption of Renal Tubular Mitochondrial Quality Control by Myo-Inositol Oxygenase in Diabetic Kidney Disease

Ming Zhan et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

Review Cell Biology

Autophagy and human diseases

Peidu Jiang et al.

CELL RESEARCH (2014)

Review Urology & Nephrology

The link between acute kidney injury and chronic kidney disease

Linda Y. Belayev et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2014)

Article Biochemistry & Molecular Biology

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

Wenxian Wu et al.

EMBO REPORTS (2014)

Article Medicine, Research & Experimental

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

Sian M. Henson et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Biochemistry & Molecular Biology

Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway

Bo-Lin Chen et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2014)

Article Chemistry, Multidisciplinary

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Rachid Skouta et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Review Urology & Nephrology

Regulated Cell Death in AKI

Andreas Linkermann et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Article Urology & Nephrology

Delayed Administration of a Single Dose of Lithium Promotes Recovery from AKI

Hui Bao et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Article Urology & Nephrology

Autophagy Regulates TGF-β Expression and Suppresses Kidney Fibrosis Induced by Unilateral Ureteral Obstruction

Yan Ding et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Article Urology & Nephrology

Regulation of lipid accumulation by AMK-activated kinase in high fat diet-induced kidney injury

Anne-Emilie Decleves et al.

KIDNEY INTERNATIONAL (2014)

Article Multidisciplinary Sciences

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Joseph D. Mancias et al.

NATURE (2014)

Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

Review Cell Biology

Self-consumption: the interplay of autophagy and apoptosis

Guillermo Marino et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Multidisciplinary Sciences

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

Kara G. Lassen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

Florian Grahammer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Synchronized renal tubular cell death involves ferroptosis

Andreas Linkermann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Cell Biology

Molecular mechanisms of regulated necrosis

Lorenzo Galluzzi et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)

Review Urology & Nephrology

Autophagy in Acute Kidney Injury

Man J. Livingston et al.

SEMINARS IN NEPHROLOGY (2014)

Review Cell Biology

NAD+ and sirtuins in aging and disease

Shin-ichiro Imai et al.

TRENDS IN CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

Joungmok Kim et al.

Article Biochemistry & Molecular Biology

Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagy

E. Keil et al.

CELL DEATH AND DIFFERENTIATION (2013)

Article Biochemistry & Molecular Biology

Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

F. Basit et al.

CELL DEATH AND DIFFERENTIATION (2013)

Article Urology & Nephrology

The RIP1-Kinase Inhibitor Necrostatin-1 Prevents Osmotic Nephrosis and Contrast-Induced AKI in Mice

Andreas Linkermann et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

Article Urology & Nephrology

Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions

Kosuke Yamahara et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

Letter Urology & Nephrology

Non-apoptotic effects of antiapoptotic agent zVAD-fmk in renal injury

Gur P. Kaushal et al.

KIDNEY INTERNATIONAL (2013)

Article Cell Biology

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

Ryan C. Russell et al.

NATURE CELL BIOLOGY (2013)

Review Cell Biology

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

Yosef Shiloh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Letter Medicine, General & Internal

Autophagy in Human Health and Disease REPLY

Augustine M. K. Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Multidisciplinary Sciences

mTOR-Controlled Autophagy Requires Intracellular Ca2+ Signaling

Jean-Paul Decuypere et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

Gina M. Howell et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

Yang Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

Andreas Linkermann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Medicine, General & Internal

MECHANISMS OF DISEASE Autophagy in Human Health and Disease

Augustine M. K. Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Physiology

Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury

Masayuki Ishihara et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

Article Pathology

Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

Lyndsay Murrow et al.

Annual Review of Pathology-Mechanisms of Disease (2012)

Article Biochemistry & Molecular Biology

Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death

Ozlem Oral et al.

APOPTOSIS (2012)

Article Cell Biology

AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization

Hildegard I. D. Mack et al.

AUTOPHAGY (2012)

Review Biochemistry & Molecular Biology

Calpains - An elaborate proteolytic system

Yasuko Ono et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2012)

Article Pharmacology & Pharmacy

AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney

J. Lempiainen et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Biochemistry & Molecular Biology

Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response

V. Pagliarini et al.

CELL DEATH AND DIFFERENTIATION (2012)

Article Pharmacology & Pharmacy

Involvement of autophagy in the pharmacological effects of the mTOR inhibitor everolimus in acute kidney injury

Shunsaku Nakagawa et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Autophagy Promotes Intracellular Degradation of Type I Collagen Induced by Transforming Growth Factor (TGF)-β1

Sung Il Kim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells

Muhammad Jadoon Khan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Immunology

Tryptophan Depletion and the Kinase GCN2 Mediate IFN-γ-Induced Autophagy

Sophie Fougeray et al.

JOURNAL OF IMMUNOLOGY (2012)

Article Urology & Nephrology

Inhibition of MTOR Disrupts Autophagic Flux in Podocytes

Davide P. Cina et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)

Article Urology & Nephrology

Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity

Jinu Kim et al.

KIDNEY INTERNATIONAL (2012)

Article Urology & Nephrology

Autophagy in proximal tubules protects against acute kidney injury

Man Jiang et al.

KIDNEY INTERNATIONAL (2012)

Review Biochemistry & Molecular Biology

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

Sebastian Alers et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Review Cell Biology

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

Patrice Codogno et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Urology & Nephrology

The role of autophagy in unilateral ureteral obstruction rat model

Wan-Young Kim et al.

NEPHROLOGY (2012)

Article Urology & Nephrology

Caspase-3-Independent Internucleosomal DNA Fragmentation in Ischemic Acute Kidney Injury

Taiko Yoshida et al.

NEPHRON EXPERIMENTAL NEPHROLOGY (2012)

Article Multidisciplinary Sciences

PARP-1 Modulation of mTOR Signaling in Response to a DNA Alkylating Agent

Chantal Ethier et al.

PLOS ONE (2012)

Article Urology & Nephrology

Nec-1 Protects against Nonapoptotic Cell Death in Cisplatin-Induced Kidney Injury

Vivian Regina Tristao et al.

RENAL FAILURE (2012)

Article Multidisciplinary Sciences

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

Richard C. Wang et al.

SCIENCE (2012)

Article Cell Biology

Metabolic Stress in Autophagy and Cell Death Pathways

Brian J. Altman et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

Article Physiology

zVAD-fmk prevents cisplatin-induced cleavage of autophagy proteins but impairs autophagic flux and worsens renal function

Christian Herzog et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2012)

Review Biochemistry & Molecular Biology

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima et al.

Article Cell Biology

Autophagy-deficient mice develop multiple liver tumors

Akito Takamura et al.

GENES & DEVELOPMENT (2011)

Article Biochemistry & Molecular Biology

Identification of Small Molecule Inhibitors of Phosphatidylinositol 3-Kinase and Autophagy

Thomas Farkas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Medicine, Research & Experimental

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

Markus Goedel et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Medicine, Research & Experimental

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

Ken Inoki et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Pharmacology & Pharmacy

TNFα-Induced Necroptosis and Autophagy via Supression of the p38-NF-κB Survival Pathway in L929 Cells

Yuan-Chao Ye et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2011)

Article Urology & Nephrology

Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury

Tomonori Kimura et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

Review Urology & Nephrology

Apoptosis and acute kidney injury

Andrea Havasi et al.

KIDNEY INTERNATIONAL (2011)

Review Biochemistry & Molecular Biology

Chemical modulators of autophagy as biological probes and potential therapeutics

Angeleen Fleming et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Multidisciplinary Sciences

TFEB Links Autophagy to Lysosomal Biogenesis

Carmine Settembre et al.

SCIENCE (2011)

Article Pathology

Autophagy Is a Component of Epithelial Cell Fate in Obstructive Uropathy

Ling Li et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

Article Biochemistry & Molecular Biology

Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: Implication in pathogenesis of COPD

Jae-woong Hwang et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)

Editorial Material Cell Biology

ATM engages the TSC2/mTORC1 signaling node to regulate autophagy

Angela Alexander et al.

AUTOPHAGY (2010)

Article Cell Biology

Control of basal autophagy by calpain1 mediated cleavage of ATG5

Hong-guang Xia et al.

AUTOPHAGY (2010)

Article Biochemistry & Molecular Biology

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

S. Luo et al.

CELL DEATH AND DIFFERENTIATION (2010)

Article Cell Biology

The role of the Atg1/ULK1 complex in autophagy regulation

Noboru Mizushima

CURRENT OPINION IN CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP

Jemma L. Webber et al.

EMBO JOURNAL (2010)

Review Biochemistry & Molecular Biology

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

Viktor I. Korolchuk et al.

FEBS LETTERS (2010)

Article Biochemistry & Molecular Biology

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

Claudia Rose et al.

HUMAN MOLECULAR GENETICS (2010)

Article Cell Biology

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

Sabrina Di Bartolomeo et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Cell Biology

Endogenous HMGB1 regulates autophagy

Daolin Tang et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Medicine, Research & Experimental

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

Shinji Kume et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Medicine, Research & Experimental

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

Bjoern Hartleben et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Review Biochemistry & Molecular Biology

Autophagy and the Integrated Stress Response

Guido Kroemer et al.

MOLECULAR CELL (2010)

Review Urology & Nephrology

Renal fibrosis: novel insights into mechanisms and therapeutic targets

Peter Boor et al.

NATURE REVIEWS NEPHROLOGY (2010)

Review Physiology

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Brinda Ravikumar et al.

PHYSIOLOGICAL REVIEWS (2010)

Article Multidisciplinary Sciences

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

Hiyaa Singhee Ghosh et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

ATM Activation by Oxidative Stress

Zhi Guo et al.

SCIENCE (2010)

Editorial Material Cell Biology

p65/RelA binds and activates the beclin 1 promoter

Tamara Copetti et al.

AUTOPHAGY (2009)

Article Biochemistry & Molecular Biology

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

Sudan He et al.

Review Biochemistry & Molecular Biology

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

G. Kroemer et al.

CELL DEATH AND DIFFERENTIATION (2009)

Article Biochemistry & Molecular Biology

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

J. M. Vicencio et al.

CELL DEATH AND DIFFERENTIATION (2009)

Review Urology & Nephrology

Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy

Robert L. Chevalier et al.

KIDNEY INTERNATIONAL (2009)

Article Transplantation

Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells

Takahisa Kawakami et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2009)

Article Multidisciplinary Sciences

A Gene Network Regulating Lysosomal Biogenesis and Function

Marco Sardiello et al.

SCIENCE (2009)

Article Physiology

Cyclophilin D gene ablation protects mice from ischemic renal injury

Kishor Devalaraja-Narashimha et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)

Article Biochemistry & Molecular Biology

JNK1-mediated phosphorylation of BcI-2 regulates starvation-induced autophagy

Yongjie Wei et al.

MOLECULAR CELL (2008)

Article Biochemistry & Molecular Biology

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

Andrea Williams et al.

NATURE CHEMICAL BIOLOGY (2008)

Review Biochemistry & Molecular Biology

The FoxO code

D. R. Calnan et al.

ONCOGENE (2008)

Article Multidisciplinary Sciences

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

In Hye Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

Atsuko Nakai et al.

NATURE MEDICINE (2007)

Article Biochemistry & Molecular Biology

Regulation of autophagy by the inositol trisphosphate receptor

A. Criollo et al.

CELL DEATH AND DIFFERENTIATION (2007)

Article Immunology

The role of immunosuppressive drugs in aggravating renal ischemia and reperfusion injury

G. M. Goncalves et al.

TRANSPLANTATION PROCEEDINGS (2007)

Article Cell Biology

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

Shida Yousefi et al.

NATURE CELL BIOLOGY (2006)

Article Multidisciplinary Sciences

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Masaaki Komatsu et al.

NATURE (2006)

Article Multidisciplinary Sciences

Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience

B Nayak et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

S Pattingre et al.

Article Biochemistry & Molecular Biology

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

A Degterev et al.

NATURE CHEMICAL BIOLOGY (2005)

Article Cell Biology

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

M Komatsu et al.

JOURNAL OF CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Inhibition of macroautophagy triggers apoptosis

P Boya et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Physiology

Poly(ADP-ribose) polymerase-1 gene ablation protects mice from ischemic renal injury

JF Zheng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)

Article Biochemistry & Molecular Biology

TSC2 mediates cellular energy response to control cell growth and survival

K Inoki et al.

Article Cell Biology

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Y Zhang et al.

NATURE CELL BIOLOGY (2003)

Article Physiology

Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells

W Lieberthal et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2001)

Article Physiology

Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats

DR Martin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2000)