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Tryptophan Depletion and the Kinase GCN2 Mediate IFN-γ-Induced Autophagy
Sophie Fougeray et al.
JOURNAL OF IMMUNOLOGY (2012)
Inhibition of MTOR Disrupts Autophagic Flux in Podocytes
Davide P. Cina et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)
Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity
Jinu Kim et al.
KIDNEY INTERNATIONAL (2012)
Autophagy in proximal tubules protects against acute kidney injury
Man Jiang et al.
KIDNEY INTERNATIONAL (2012)
Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury
Andreas Linkermann et al.
KIDNEY INTERNATIONAL (2012)
Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks
Sebastian Alers et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Canonical and non-canonical autophagy: variations on a common theme of self-eating?
Patrice Codogno et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
The role of autophagy in unilateral ureteral obstruction rat model
Wan-Young Kim et al.
NEPHROLOGY (2012)
Caspase-3-Independent Internucleosomal DNA Fragmentation in Ischemic Acute Kidney Injury
Taiko Yoshida et al.
NEPHRON EXPERIMENTAL NEPHROLOGY (2012)
Aristolochic Acid I Induced Autophagy Extenuates Cell Apoptosis via ERK 1/2 Pathway in Renal Tubular Epithelial Cells
Youjia Zeng et al.
PLOS ONE (2012)
Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition
Kevin Bray et al.
PLOS ONE (2012)
PARP-1 Modulation of mTOR Signaling in Response to a DNA Alkylating Agent
Chantal Ethier et al.
PLOS ONE (2012)
Nec-1 Protects against Nonapoptotic Cell Death in Cisplatin-Induced Kidney Injury
Vivian Regina Tristao et al.
RENAL FAILURE (2012)
Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation
Richard C. Wang et al.
SCIENCE (2012)
Metabolic Stress in Autophagy and Cell Death Pathways
Brian J. Altman et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)
zVAD-fmk prevents cisplatin-induced cleavage of autophagy proteins but impairs autophagic flux and worsens renal function
Christian Herzog et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2012)
Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated
Jean-Paul Decuypere et al.
AUTOPHAGY (2011)
Autophagy: Renovation of Cells and Tissues
Noboru Mizushima et al.
CELL (2011)
Autophagy-deficient mice develop multiple liver tumors
Akito Takamura et al.
GENES & DEVELOPMENT (2011)
Identification of Small Molecule Inhibitors of Phosphatidylinositol 3-Kinase and Autophagy
Thomas Farkas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice
Markus Goedel et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
Ken Inoki et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
TNFα-Induced Necroptosis and Autophagy via Supression of the p38-NF-κB Survival Pathway in L929 Cells
Yuan-Chao Ye et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2011)
Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury
Tomonori Kimura et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)
Apoptosis and acute kidney injury
Andrea Havasi et al.
KIDNEY INTERNATIONAL (2011)
cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms
Maria Feoktistova et al.
MOLECULAR CELL (2011)
Chemical modulators of autophagy as biological probes and potential therapeutics
Angeleen Fleming et al.
NATURE CHEMICAL BIOLOGY (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
Carmine Settembre et al.
SCIENCE (2011)
Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction
Jinu Kim et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2011)
Autophagy Is a Component of Epithelial Cell Fate in Obstructive Uropathy
Ling Li et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: Implication in pathogenesis of COPD
Jae-woong Hwang et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)
ATM engages the TSC2/mTORC1 signaling node to regulate autophagy
Angela Alexander et al.
AUTOPHAGY (2010)
Control of basal autophagy by calpain1 mediated cleavage of ATG5
Hong-guang Xia et al.
AUTOPHAGY (2010)
ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy
Liang Qin et al.
AUTOPHAGY (2010)
Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model
Hanna Shevalye et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria
Cesar Cardenas et al.
CELL (2010)
Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL
S. Luo et al.
CELL DEATH AND DIFFERENTIATION (2010)
The role of the Atg1/ULK1 complex in autophagy regulation
Noboru Mizushima
CURRENT OPINION IN CELL BIOLOGY (2010)
Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP
Jemma L. Webber et al.
EMBO JOURNAL (2010)
Chronic lithium treatment protects the rat kidney against ischemia/reperfusion injury: The role of nitric oxide and cyclooxygenase pathways
Saman Shafaat Talab et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2010)
Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems
Viktor I. Korolchuk et al.
FEBS LETTERS (2010)
Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease
Claudia Rose et al.
HUMAN MOLECULAR GENETICS (2010)
The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
Sabrina Di Bartolomeo et al.
JOURNAL OF CELL BIOLOGY (2010)
Endogenous HMGB1 regulates autophagy
Daolin Tang et al.
JOURNAL OF CELL BIOLOGY (2010)
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
Shinji Kume et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
Bjoern Hartleben et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance
Laura Bonapace et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Autophagy and the Integrated Stress Response
Guido Kroemer et al.
MOLECULAR CELL (2010)
Renal fibrosis: novel insights into mechanisms and therapeutic targets
Peter Boor et al.
NATURE REVIEWS NEPHROLOGY (2010)
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
Brinda Ravikumar et al.
PHYSIOLOGICAL REVIEWS (2010)
SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
Hiyaa Singhee Ghosh et al.
PLOS ONE (2010)
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
E. Wirawan et al.
CELL DEATH & DISEASE (2010)
p65/RelA binds and activates the beclin 1 promoter
Tamara Copetti et al.
AUTOPHAGY (2009)
To die or to live The dual role of poly (ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage
Qing Huang et al.
AUTOPHAGY (2009)
Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
YoungSik Cho et al.
CELL (2009)
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
Sudan He et al.
CELL (2009)
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
G. Kroemer et al.
CELL DEATH AND DIFFERENTIATION (2009)
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
J. M. Vicencio et al.
CELL DEATH AND DIFFERENTIATION (2009)
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
Einat Zalckvar et al.
EMBO REPORTS (2009)
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis
Virginie M. S. Betin et al.
JOURNAL OF CELL SCIENCE (2009)
Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy
Robert L. Chevalier et al.
KIDNEY INTERNATIONAL (2009)
Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1
Gianfranco Distefano et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells
Takahisa Kawakami et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2009)
The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells
D-D Li et al.
ONCOGENE (2009)
A Gene Network Regulating Lysosomal Biogenesis and Function
Marco Sardiello et al.
SCIENCE (2009)
RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
Duan-Wu Zhang et al.
SCIENCE (2009)
Cyclophilin D gene ablation protects mice from ischemic renal injury
Kishor Devalaraja-Narashimha et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)
Autophagy plays a protective role during zVAD-induced necrotic cell death
You-Tong Wu et al.
AUTOPHAGY (2008)
Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation
Yongjie Wei et al.
AUTOPHAGY (2008)
JNK1-mediated phosphorylation of BcI-2 regulates starvation-induced autophagy
Yongjie Wei et al.
MOLECULAR CELL (2008)
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Andrea Williams et al.
NATURE CHEMICAL BIOLOGY (2008)
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
In Hye Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
Atsuko Nakai et al.
NATURE MEDICINE (2007)
Regulation of autophagy by the inositol trisphosphate receptor
A. Criollo et al.
CELL DEATH AND DIFFERENTIATION (2007)
The role of immunosuppressive drugs in aggravating renal ischemia and reperfusion injury
G. M. Goncalves et al.
TRANSPLANTATION PROCEEDINGS (2007)
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
Shida Yousefi et al.
NATURE CELL BIOLOGY (2006)
Rapamycin delays but does not prevent recovery from acute renal failure: Role of acquired tubular resistance
Wilfred Lieberthal et al.
TRANSPLANTATION (2006)
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
Kurt Degenhardt et al.
CANCER CELL (2006)
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara et al.
NATURE (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu et al.
NATURE (2006)
Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience
B Nayak et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
S Pattingre et al.
CELL (2005)
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
A Degterev et al.
NATURE CHEMICAL BIOLOGY (2005)
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
M Komatsu et al.
JOURNAL OF CELL BIOLOGY (2005)
Inhibition of macroautophagy triggers apoptosis
P Boya et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Poly(ADP-ribose) polymerase-1 gene ablation protects mice from ischemic renal injury
JF Zheng et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
Y Zhang et al.
NATURE CELL BIOLOGY (2003)
Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells
W Lieberthal et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2001)
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
N Holler et al.
NATURE IMMUNOLOGY (2000)
Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats
DR Martin et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2000)