Journal
CARBOHYDRATE POLYMERS
Volume 143, Issue -, Pages 270-278Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.02.015
Keywords
Electrospinning; Poly(epsilon-caprolactone)/nanocellulose; Mineralization; Scaffolds; Hydroxyapatite
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Funding
- National Natural Science Foundation of China [51303027]
- China Postdoctoral Science Foundation [2014M560525]
- University Scientific Research Foundation of Fujian [JK2014030]
- Opening Foundation of National Center for International Research of Micro- nano Molding Technology&Key Laboratory for Micro Molding Technology of Henan Province [MMT2016-02]
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A biomimetic nanocomposite scaffold with HA formation on the electrospun poly(epsilon-caprolactone) (PCL)/nanocellulose (NC) fibrous matrix was developed in this study. The electrospun PCL/NC fiber mat was built and then biomineralized by treatment in simulated body fluid (SBF). Using such a rapid and effective procedure, a continuous biomimetic crystalline HA layer could be successfully formed without the need of any additional chemical modification of the substrate surface. The results showed that the introduction of NC into composite fibers is an effective approach to induce the deposition of HA nucleusas well as to improve their distribution and growth of a crystalline HA layer on the fibrous scaffolds. The water contact angle (WCA) of the PCL/NC/HA scaffolds decreases with increasing NC content and mineralization time, resulting in the enhancement of their hydrophilicity. These results indicated that HA mineralized on PCL/NC fiber can be prepared directly by simply using SBF immersion. (C) 2016 Elsevier Ltd. All rights reserved.
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