Journal
BIOMOLECULES
Volume 9, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/biom9120840
Keywords
polysaccharide; composites; bone tissue engineering; stem cells; osteogenesis; angiogenesis
Categories
Funding
- German Federal Ministry of Education and Research (BMBF) program Ingenieur Nachwuchs 2015: PersoImplant [13FH019IX5]
- German Federal Ministry of Education and Research (BMBF) program Ingenieur Nachwuchs 2016: HybridKEM [13FH569IX6]
- Ministry of Culture and Science of the German State of North Rhine-Westphalia (MKW NRW) program FH Zeit fur Forschung 2016: TestMedgO [1609FHZ027]
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Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.
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