Journal
CARBOHYDRATE POLYMERS
Volume 148, Issue -, Pages 200-205Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.04.025
Keywords
Chitosan; Ultra high molecular weight; Bacteriostatic and bactericidal activity; Antibacterial mechanism
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Funding
- Fund of Characteristic Innovation Project of Guangdong Province Ordinary University [2014KTSCX111]
- Special Fund for Development of Strategic Emerging Industries in Shenzhen [CXZZ20150430093131635, JCYJ20140418091413576, NYSW20130329010039]
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Chitosan with different degree of deacetylation (DD) and ultra high molecular weight (MW >10(6)) was prepared from beta-chitin by mild deacetylation. The effects of DD of chitosan and pH value of its solution/suspension on its antibacterial activity were investigated. The results showed that the optimal pH value was 6.0 for the highest bactericidal activity. The antibacterial activity against Escherichia coli and Staphylococcus aureus of chitosan solution at pH 6.0 enhanced as the DD of chitosan increased. Same as chitosan with low MW, the antibacterial activity of chitosan with high MW in acidic solution was also due to the amino protonation and subsequently cationic formation. Its ultra long molecular chain was propitious to coat and bind the E. coli and S. aureus, and highly enhanced its antibacterial activity. E. coli and S. aureus were at first restrained and then killed by chitosan and the cells were ruptured and decomposed gradually. (C) 2016 Elsevier Ltd. All rights reserved.
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