Journal
VACCINES
Volume 8, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/vaccines8010098
Keywords
humanized mice; HIS mice; NSG; TKO; BLT; filovirus; Ebola; EBOV; Marburg; Crimean-Congo Hemorrhagic fever; Rift Valley Fever; hantavirus; VHF; hemorrhagic fever virus
Categories
Funding
- CDC emerging infectious disease research core funds
Ask authors/readers for more resources
Human immune system (HIS) mice are a subset of humanized mice that are generated by xenoengraftment of human immune cells or tissues and/or their progenitors into immunodeficient mice. Viral hemorrhagic fevers (VHFs) cause severe disease in humans, typically with high case fatality rates. HIS mouse studies have been performed to investigate the pathogenesis and immune responses to VHFs that must be handled in high-containment laboratory facilities. Here, we summarize studies on filoviruses, nairoviruses, phenuiviruses, and hantaviruses, and discuss the knowledge gained from using various HIS mouse models. Furthermore, we discuss the complexities of designing and interpreting studies utilizing HIS mice while highlighting additional questions about VHFs that can still be addressed using HIS mouse models.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available