Journal
CARBOHYDRATE POLYMERS
Volume 147, Issue -, Pages 69-78Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.03.101
Keywords
Fucoidan; Sargassum crassifolium; Padina australis; Small angle X-ray scattering; Intestinal immunomodulating activity
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Funding
- Vietnam Academy of Science and Technology [VAST.HTQT.NHATBAN.02/13-15]
- Bilateral Program in Japan Society of Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [26450183] Funding Source: KAKEN
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We studied the structure of fucoidans extracted from two brown seaweed species, Sargassum crassifolium and Padina australis, and their intestinal immunomodulating activity via Peyer's patch cells of C3H/HeJ mice. ESI-MS analysis indicated that the dominant structure of both fucoidans has a backbone of alpha- (1 -> 4)-linked and alpha-(1 -> 3)-linked L-fucose residues and sulfate groups are attached at the C-2 and C-4 positions; branches of fucoidan from S. crassifolium are galactose residues with (1 -> 4)-linkage and branching points are at C-4 of fucose, while fucoidan from P. australis, branches are sulfated galactose-fucose disaccharides and sulfated galactose monosaccharides attached to the main chain through (1 -> 3)- or (1 -> 4)- linkages. According to small angle X-ray scattering (SAXS) measurements, the two fucoidans have a branched structure. We simulated them with molecular models based on our proposed primary structure. These fucoidan samples have the ability to stimulate intestinal immunological activity via Peyer's patch cells. (C) 2016 Elsevier Ltd. All rights reserved.
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