Journal
SCIENCE IMMUNOLOGY
Volume 5, Issue 45, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciimmunol.aay4209
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Funding
- NIH/National Institute of Allergy and Infectious Diseases (NIAID) [U19 AI104209, R01 AI125567, R01 AI127877, R01 AI130398, R01 AI140134, R01 HL118612, U01 AI140498, UM1 AI130839]
- Big Data for Human Health Seed Grant from the Li Ka Shing Foundation
- Crown Family Foundation
- Sean N. Parker Center for Allergy and Asthma Research at Stanford University Medical Center
- Food Allergy Research and Education Center of Excellence
- Myra Reinhard Foundation
- End Allergies Together
- Hartman Family Foundation
- Naddisy Foundation
- Levin Family Foundation
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B cells in human food allergy have been studied predominantly in the blood. Little is known about IgE B cells or plasma cells in tissues exposed to dietary antigens. We characterized IgE clones in blood, stomach, duodenum, and esophagus of 19 peanut-allergic patients, using high-throughput DNA sequencing. IgE(+) cells in allergic patients are enriched in stomach and duodenum, and have a plasma cell phenotype. Clonally related IgE(+) and non-IgE-expressing cell frequencies in tissues suggest local isotype switching, including transitions between IgA and IgE isotypes. Highly similar antibody sequences specific for peanut allergen Ara h 2 are shared between patients, indicating that common immunoglobulin genetic rearrangements may contribute to pathogenesis. These data define the gastrointestinal tract as a reservoir of IgE(+) B lineage cells in food allergy.
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