Journal
CARBOHYDRATE POLYMERS
Volume 151, Issue -, Pages 1240-1244Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.06.066
Keywords
Core-shell electrospinning; Cellulose acetate phthalate; Polyurethane; Intravaginal drug delivery
Categories
Funding
- Jiangsu specially-appointed professorship program [Sujiaoshi [2012]34]
- National Natural Science Foundation of China [31200451, 31400505]
- Natural Science Foundation of Jiangsu Province [BK20140957]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP)
- Scientific Research Staring Foundation for the Returned Overseas Chinese Scholars, Ministry of Education of China
- Jiangsu key lab of biomass-based green fuels and chemicals [JSBGFC14001]
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In this study we present the use of co-axial electrospinning to produce core-shell composite micro-/nano fibers of polyurethane (PU) and cellulose acetate phthalate (CAP). The designed fibers possess enhanced mechanical properties with a tensile strength of 13.27 +/- 2.32 MPa, which is a clear improvement over the existing CAP fibers that suffer from a poor mechanical strength (0.2 +/- 0.03 MPa). The CAP imparts pH responsiveness to the core-shell structure giving the fibers potential for semen sensitive (intravaginal) drug delivery. (C) 2016 Elsevier Ltd. All rights reserved.
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