Journal
CARBOHYDRATE POLYMERS
Volume 151, Issue -, Pages 392-400Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.05.084
Keywords
Cellulose; Cross-linking; Cryogel; Hydrogel; Swelling; Controlled release
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Funding
- Romanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI [PN-II-RU-TE-2014-4-0558]
- French National Agency for Research (ANR), Nanocel project [ANR-09-HABISOL-010]
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Porous cellulose matrices were prepared via cellulose dissolution in 8 wt% NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated. (C) 2016 Elsevier Ltd. All rights reserved.
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