Journal
CARBOHYDRATE POLYMERS
Volume 144, Issue -, Pages 223-229Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.02.062
Keywords
Graphene oxide; Reduce graphene oxide; Dextran; Photo-chemotherapy
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Funding
- National Natural Science Foundation of China [21474012, 51273037, 50903012]
- Jilin Science and Technology Bureau [20130206074GX, 20120729]
- Jilin Human Resources and Social Security Bureau [201125020]
- Jilin Environmental Protection Bureau [201127]
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Graphene-based nanocarriers show great potential in photo-chemotherapy, however, to prepare desired reduced graphene oxide (rGO) nanoparticles in a facile way is still a challenge. Herein, a novel strategy has been presented to prepare rGO nanoparticle using dextran (Dex) as a reducing agent. In this strategy, Dex was directly conjugated on rGO by hydrogen bond and then self-assemble to form rGO/Dex nanoparticles. After decorated by dextran, rGO-based nanoparticles not only show excellent biocompatibility but also can load anticancer drug for photo-chemotherapy. The data of fourier transform infrared (FT-IR) analysis, Raman spectrum analysis, thermos-gravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), the transmission electron microscope (TEM) image and dynamic light scattering (DLS) measurements power fully proved that the stable rGO-based nanoparticles with desired nanosize have been successfully prepared. To verify the photo-chemotherapy, anticancer drug, doxorubicin (DOX), has been loaded on rGO/Dex nanoparticles (rGO/DOX/Dex). And RGD, a kind of oligopeptide which can improve the intracellular uptake by alpha(v)beta(3) recognition, also has been introduced (rGO/DOX/RDex). Compared with single chemotherapy, rGO/DOX/Dex and rGO/DOX/RDex combining the local specific chemotherapy and external near-infrared (NIR) photo-thermal therapy show higher therapeutic efficacy, endowing the desired rGO-based nanoparticle with great potential for cancer treatments. (C) 2016 Elsevier Ltd. All rights reserved.
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