Journal
CARBOHYDRATE POLYMERS
Volume 144, Issue -, Pages 59-67Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.02.029
Keywords
Glycol chitosan; Thermogel; Sol-gel transition; Physical crosslinking; Photo-crosslinking
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Funding
- INNOPOLIS Foundation grant - Korean government (Ministry of Science, ICT & Future Planning) through WINNOVA [2014DD023]
- Development of High Medical Technology Project of KHIDI, Korea [HI14C2755]
- Cooperative Research Program for Agriculture Science and Technology Development [PJ0099562014]
- Rural Development Administration, Republic of Korea
- Chungnam National University
- Ministry of Science, ICT & Future Planning, Republic of Korea [2014DD023] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The major limitations of typical thermogelling polymers for practical applications are low gel stability and weak mechanical properties under physiological conditions. In this study, we have synthesized a new polysaccharide-based thermogelling polymer that can be photo-crosslinked by UV irradiation to form a mechanically resilient and elastic hydrogel. Methacrylated hexanoyl glycol chitosan (M-HGC), was synthesized by a series of chemical modifications, N-hexanoylation and N-methacrylation, of glycol chitosan (GC). Various M-HGC polymers with different methacryl group contents were synthesized and their thermogelling and photo-crosslinkable properties were evaluated. The M-HGCs demonstrated a thermo-reversible sol-gel transition behavior in aqueous solutions. The thermally-induced hydrogels could be chemically crosslinked by UV-triggered photo-crosslinking. From the cytotoxicity studies using MTT and the live/dead assay, the M-HGC hydrogels showed non-cytotoxicity. These photo-crosslinkable thermogelling M-HGC polymers may hold great promises for various biomedical applications, such as an injectable delivery system and 3D cell culture. (C) 2016 Elsevier Ltd. All rights reserved.
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