Journal
CARBOHYDRATE POLYMERS
Volume 145, Issue -, Pages 114-120Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.02.065
Keywords
Bacterial cellulose; Tetracycline hydrochloride; Controlled release; Antibacterial activity; Biocompatibility
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Funding
- National Natural Science Foundation of China [51401109]
- High-level Talent Project of Nanjing Forestry University [GXL201301]
- Major Program of the Natural Science Foundation of Jiangsu Higher Education of China [14KJB430018]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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Bacterial cellulose (BC) is widely used in biomedical applications. In this study, we prepared an antibiotic drug tetracycline hydrochloride (TCH)-loaded bacterial cellulose (BC) composite membranes, and evaluated the drug release, antibacterial activity and biocompatibility. The structure and morphology of the fabricated BC-TCH composite membranes were characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The TCH release results show that the incorporation of BC matrix to load TCH is able to control the release. In vitro antibacterial assay demonstrate that the developed BC-TCH composites displayed excellent antibacterial activity solely associated with the loaded TCH drug. More importantly, the BC-TCH composite membranes display good biocompatibility. These characteristics of BC-TCH composite membranes indicate that they may successfully serve as wound dressings and other medical biomaterials. (C) 2016 Elsevier Ltd. All rights reserved.
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