Journal
CARBOHYDRATE POLYMERS
Volume 152, Issue -, Pages 119-128Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.07.002
Keywords
Chitosan; Biomaterial; Hydrogel; Nerve regeneration; Electrodeposition
Categories
Funding
- Faculty of Process and Environmental Engineering at Lodz University of Technology
- Foundation for Polish Science [73/UD/SKILLS/2014]
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In this investigation, we report on a fabrication method of epineurium-mimicking tubular conduits based on electrodeposition from chitosan solution. The pre -enrichment of electrodeposition solution with hyaluronic acid and/or collagen components results in structures which structural, morphological, and physicochemical properties can be controlled. In order to determine the optimal composition of the initial chitosan solution resulting in conduits meeting the requirements imposed on peripheral nerve implants, we perform chemical, physical, and biological studies. Both the molecular weight of hyaluronic acid and the concentration of additives are found to be crucial for the final mechanical as well as biological performance of conduits. Because, the obtained structures show biocompatibility when contacting with a mouse hippocampal cell line (mHippoE-18), we further plan to test their application potential on an animal model. (C) 2016 Elsevier Ltd. All rights reserved.
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