Journal
BIOTECHNOLOGY ADVANCES
Volume 33, Issue 8, Pages 1503-1521Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2015.07.006
Keywords
2-Dimensional printing; 3-Dimensional printing; Bioprinting; Heart valve; Hydrogel
Categories
Funding
- HH Sheikh Hamed bin Zayed Al Nahyan Program in Biological Valve Engineering
- Grainger Foundation [94381008]
- Mayo Clinic Center for Regenerative Medicine
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Heart valve tissue engineering could be a possible solution for the limitations of mechanical and biological prostheses, which are commonly used for heart valve replacement. In tissue engineering, cells are seeded into a 3-dimensional platform, termed the scaffold, to make the engineered tissue construct. However, mimicking the mechanical and spatial heterogeneity of a heart valve structure in a fabricated scaffold with uniform cell distribution is daunting when approached conventionally. Bioprinting is an emerging technique that can produce biological products containing matrix and cells, together or separately with morphological, structural and mechanical diversity. This advance increases the possibility of fabricating the structure of a heart valve in vitro and using it as a functional tissue construct for implantation. This review describes the use of bioprinting technology in heart valve tissue engineering. (C) 2015 Elsevier Inc. All rights reserved.
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