Journal
CARBOHYDRATE POLYMERS
Volume 136, Issue -, Pages 618-629Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.08.070
Keywords
Nitrocellulose liquid bandage; Wound dressing; Nano porous; Wound healing
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Funding
- National Nature Science Foundation of China [30973591, 81271691]
- International Science & Technology Cooperation Program of China [2011DFG33320]
- Scientific Research Fund of Fujian Provincial Education Department of China [JA14392]
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Nitrocellulose liquid bandage (L-Bandage) is extensively used in hard-to-cover cuts and wounds management, owing to its flexibility, softness, transparency, and conformability. However, evidence supporting their mechanisms of action as wound dressing is scanty. This study introduces a novel nano-porous L-Bandage, and provides results from a mouse full-thickness wound model investigating its mechanism of action on wound healing. Different characteristics, such as porosity, mechanical properties and water vapor transmission rate (WVTR) were determined. The L-Bandage formed film had a porous network structure with mean diameter of 18 nm that could effectively prevent the bacterial invasion, and favorable properties of tensile strength, elongation, and WVTR. The L-Bandage treated wound exhibited accelerated healing, with reduced inflammations, enhanced wound re-epithelialization, contraction, granulation tissue formation, and rapid angiogenesis. Our data suggested that L-Bandage could serve as a promising wound dressing, because of its desirable properties for wound healing. (C) 2015 Elsevier Ltd. All rights reserved.
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