Related references
Note: Only part of the references are listed.NAMPT signaling is critical for the proangiogenic activity of tumor-associated neutrophils
Ekaterina Pylaeva et al.
INTERNATIONAL JOURNAL OF CANCER (2019)
Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer
Jing-hua Pan et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells
Cristina Travelli et al.
CANCER RESEARCH (2019)
Nicotinamide phosphoribosyltransferase expression and clinical outcome of resected stage I/II pancreatic ductal adenocarcinoma
Katelynn Davis et al.
PLOS ONE (2019)
Nicotinamide Phosphoribosyl Transferase Is Increased in Osteosarcomas and Chondrosarcomas Compared to Benign Bone and Cartilage
Andrew T. Meram et al.
ANTICANCER RESEARCH (2019)
FOXO1 functions in the regulation of nicotinamide phosphoribosyltransferase (Nampt) expression
Bora Jeong et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
Epigenetic Regulation of NAMPT by NAMPT-AS Drives Metastatic Progression in Triple-Negative Breast Cancer
Hanwen Zhang et al.
CANCER RESEARCH (2019)
NAMPT regulates PKM2 nuclear location through 14-3-3ζ: Conferring resistance to tamoxifen in breast cancer
Xin Ge et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2019)
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling
Sudhir Chowdhry et al.
NATURE (2019)
Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies
Yi Zhu et al.
PHARMACOLOGY & THERAPEUTICS (2019)
Screening common signaling pathways associated with drug resistance in non-small cell lung cancer via gene expression profile analysis
Ting Sun et al.
CANCER MEDICINE (2019)
NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Antonio Lucena-Cacace et al.
FRONTIERS IN ONCOLOGY (2019)
NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer
Xiao-qin Li et al.
FRONTIERS IN ONCOLOGY (2019)
Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling
Hongxia Liu et al.
AGING-US (2019)
Inhibition of NAMPT markedly enhances plasma-activated medium-induced cell death in human breast cancer MDA-MB-231 cells
Misaki Nagaya et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)
Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway
Rui Ma et al.
NUCLEIC ACIDS RESEARCH (2019)
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
Nathan R. Fons et al.
NATURE COMMUNICATIONS (2019)
Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis
Lydia Brandl et al.
NEOPLASIA (2019)
PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors
Gabriel Mpilla et al.
CANCERS (2019)
IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies
Elisa Bergaggio et al.
BLOOD (2019)
Increased nicotinamide adenine dinucleotide pool promotes colon cancer progression by suppressing reactive oxygen species level
Sun M. Hong et al.
CANCER SCIENCE (2019)
Genomic and tumor biological aspects of the anticancer nicotinamide phosphoribosyltransferase inhibitor FK866 in resistant human colorectal cancer cells
Yoko Ogino et al.
GENOMICS (2019)
High expression of NAMPT in adult T-cell leukemia/lymphoma and anti-tumor activity of a NAMPT inhibitor
Tomohiro Kozako et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2019)
The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target
Lydia Brandl et al.
MEDICAL ONCOLOGY (2019)
Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent
Anne-Julie Cloux et al.
Oncotarget (2019)
Selective targeting of NAMPT by KPT-9274 in acute myeloid leukemia
Shaneice R. Mitchel et al.
BLOOD ADVANCES (2019)
Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenstrom Macroglobulinemia
Na Li et al.
CLINICAL CANCER RESEARCH (2019)
Rho GTPase effectors and NAD metabolism in cancer immune suppression
Mahmoud Chaker et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2018)
Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma
Valentina Audrito et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)
Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma
Valentina Audrito et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)
Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype
Mickael Ohanna et al.
GENES & DEVELOPMENT (2018)
DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade
Mehdi Touat et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Inhibition of NAMPT sensitizes MOLT4 leukemia cells for etoposide treatment through the SIRT2-p53 pathway
Theresa Grohmann et al.
LEUKEMIA RESEARCH (2018)
The role of extracellular and intracellular Nicotinamide phosphoribosyl-transferase in cancer: Diagnostic and therapeutic perspectives and challenges
Maria Dalamaga et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2018)
Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition
Weixuan Wang et al.
MOLECULAR & CELLULAR PROTEOMICS (2018)
Expression of NAMPT is associated with breast invasive ductal carcinoma development and prognosis
Shao-Jie Zhou et al.
ONCOLOGY LETTERS (2018)
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is a novel marker for patients with BRAF-mutated metastatic melanoma
Valentina Audrito et al.
Oncotarget (2018)
CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools
Jeffrey P. Chmielewski et al.
MOLECULAR CANCER RESEARCH (2018)
EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
Aparna Gorthi et al.
NATURE (2018)
Genotype-targeted local therapy of glioma
Ganesh M. Shankar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The NAD(+) Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis
J. Patrick Murphy et al.
CELL REPORTS (2018)
FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells
Bin Zhang et al.
ONCOLOGY LETTERS (2018)
Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model
Denise Haslinger et al.
MOLECULAR AUTISM (2018)
NAD Metabolism in Cancer Therapeutics
Keisuke Yaku et al.
FRONTIERS IN ONCOLOGY (2018)
Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites
Daniela Buonvicino et al.
CELL CHEMICAL BIOLOGY (2018)
NAMPT Is a Potent Oncogene in Colon Cancer Progression that Modulates Cancer Stem Cell Properties and Resistance to Therapy through Sirt1 and PARP
Antonio Lucena-Cacace et al.
CLINICAL CANCER RESEARCH (2018)
Selective Cytotoxicity of the NAMPT Inhibitor FK866 Toward Gastric Cancer Cells With Markers of the Epithelial-Mesenchymal Transition, Due to Loss of NAPRT
Jooyoung Lee et al.
GASTROENTEROLOGY (2018)
Autophagic homeostasis is required for the pluripotency of cancer stem cells
Tanveer Sharif et al.
AUTOPHAGY (2017)
Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration
Genshi Zhao et al.
MOLECULAR CANCER THERAPEUTICS (2017)
Inhibition of NAMPT decreases cell growth and enhances susceptibility to oxidative stress
Renhua Xu et al.
ONCOLOGY REPORTS (2017)
Extracellular NAMPT/Visfatin induces proliferation through ERK1/2 and AKT and inhibits apoptosis in breast cancer cells
Zafar Gholinejad et al.
PEPTIDES (2017)
Inhibition of nicotinamide phosphoribosyltransferase and depletion of nicotinamide adenine dinucleotide contribute to arsenic trioxide suppression of oral squamous cell carcinoma
Xin Yue Wang et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)
EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells
Cornelia N. Mutz et al.
ONCOTARGET (2017)
Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer
Jair Machado Espindola-Netto et al.
ONCOTARGET (2017)
NAMPT overexpression induces cancer stemness and defines a novel tumor signature for glioma prognosis
Antonio Lucena-Cacace et al.
ONCOTARGET (2017)
Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy
Jonathan Cole et al.
ONCOTARGET (2017)
Role of Nampt and Visceral Adiposity in Esophagogastric Junction Adenocarcinoma
Haijun Li et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2017)
Matrix Screen Identifies Synergistic Combination of PARP Inhibitors and Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors in Ewing Sarcoma
Christine M. Heske et al.
CLINICAL CANCER RESEARCH (2017)
The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma
Hailong Zhao et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
Extracellular NAMPT/visfatin causes p53 deacetylation via NAD production and SIRT1 activation in breast cancer cells
Kiarash Behrouzfar et al.
CELL BIOCHEMISTRY AND FUNCTION (2017)
Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Francesco Piacente et al.
CANCER RESEARCH (2017)
The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion-Mediated Cytotoxicity
Kensuke Tateishi et al.
CANCER RESEARCH (2017)
Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-β-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma
Rodney E. Shackelford et al.
ANTICANCER RESEARCH (2017)
Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells
Tove Ullmark et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
The NAD+ salvage pathway modulates cancer cell viability via p73
T. Sharif et al.
CELL DEATH AND DIFFERENTIATION (2016)
NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer
S. M. Hong et al.
ONCOGENE (2016)
Biomarker triplet NAMPT/VEGF/HER2 as a de novo detection panel for the diagnosis and prognosis of human breast cancer
Yanyan Zhu et al.
ONCOLOGY REPORTS (2016)
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors
Sara Duarte-Pereira et al.
ONCOTARGET (2016)
Regulation of the Nampt-mediated NAD salvage pathway and its therapeutic implications in pancreatic cancer
Huai-Qiang Ju et al.
CANCER LETTERS (2016)
Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma
Kensuke Tateishi et al.
CLINICAL CANCER RESEARCH (2016)
Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenstrom Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status
Michele Cea et al.
CLINICAL CANCER RESEARCH (2016)
Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities
Hang Chen et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2016)
Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth
Omran Abu Aboud et al.
MOLECULAR CANCER THERAPEUTICS (2016)
An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma
Amit D. Gujar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT
Marine Barraud et al.
ONCOTARGET (2016)
Cytoplasmic proliferating cell nuclear antigen connects glycolysis and cell survival in acute myeloid leukemia
Delphine Ohayon et al.
SCIENTIFIC REPORTS (2016)
Inhibitor of Nicotinamide Phosphoribosyltransferase Sensitizes Glioblastoma Cells to Temozolomide via Activating ROS/JNK Signaling Pathway
Jun Feng et al.
BIOMED RESEARCH INTERNATIONAL (2016)
Efficacy and Safety of AP0866 in Patients With Refractory or Relapsed Cutaneous T-Cell Lymphoma: A Phase 2 Clinical Trial
Simone M. Goldinger et al.
JAMA DERMATOLOGY (2016)
Nicotinamide Phosphoribosyltransferase and SirT3 Expression are increased in Well-Differentiated Thyroid Carcinomas
Rodney Shackelford et al.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2016)
Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable
Yang Xiao et al.
PLOS ONE (2016)
New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology
Anne Roulston et al.
MOLECULAR & CELLULAR ONCOLOGY (2016)
NAMPT inhibition synergizes with NQO1-targeting agents in inducing apoptotic cell death in non-small cell lung cancer cells
Liu Hui-Ying et al.
CHINESE JOURNAL OF NATURAL MEDICINES (2016)
FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells
Susanne Schuster et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation
Caroline S. Breton et al.
BIOCHIMIE (2015)
EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition
Chiara Zucal et al.
BMC CANCER (2015)
Extreme Vulnerability of IDH1 Mutant Cancers to NAD plus Depletion
Kensuke Tateishi et al.
CANCER CELL (2015)
APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells
Antonia Cagnetta et al.
CLINICAL CANCER RESEARCH (2015)
Dedifferentiation of cancer cells following recovery from a potentially lethal damage is mediated by H2S-Nampt
Elena A. Ostrakhovitch et al.
EXPERIMENTAL CELL RESEARCH (2015)
Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, Leads to Altered Carbohydrate Metabolism in Cancer Cells
Bo Tan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Physiological and pathophysiological roles of NAMPT and NAD metabolism
Antje Garten et al.
NATURE REVIEWS ENDOCRINOLOGY (2015)
Visfatin promotes osteosarcoma cell migration and invasion via induction of epithelial-mesenchymal transition
Gong Cheng et al.
ONCOLOGY REPORTS (2015)
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer
Deepak Sampath et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is a tumoural cytokine released from melanoma
Ambra A. Grolla et al.
PIGMENT CELL & MELANOMA RESEARCH (2015)
Nicotinamide phosphorybosiltransferase overexpression in thyroid malignancies and its correlation with tumor stage and with survivin/survivin DEx3 expression
Nadia Sawicka-Gutaj et al.
TUMOR BIOLOGY (2015)
NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by beta-lapachone
Z. Moore et al.
CELL DEATH & DISEASE (2015)
Regulative Effect of Nampt on Tumor Progression and Cell Viability in Human Colorectal Cancer
Xiaoqun Lv et al.
JOURNAL OF CANCER (2015)
Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia
Valentina Audrito et al.
BLOOD (2015)
The multifaceted functions of sirtuins in cancer
Angeliki Chalkiadaki et al.
NATURE REVIEWS CANCER (2015)
Nicotinamide phosphoribosyltransferase inhibitor APO866 induces C6 glioblastoma cell death via autophagy
Ping Yang et al.
PHARMAZIE (2015)
Synergy between the NAMPT Inhibitor GMX1777(8) and Pemetrexed in Non-Small Cell Lung Cancer Cells Is Mediated by PARP Activation and Enhanced NAD Consumption
Manuel Chan et al.
CANCER RESEARCH (2014)
BRCA1 as a nicotinamide adenine dinucleotide (NAD)-dependent metabolic switch in ovarian cancer
Da Li et al.
CELL CYCLE (2014)
Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors
Claudia C. S. Chini et al.
CLINICAL CANCER RESEARCH (2014)
On-Target Effect of FK866, a Nicotinamide Phosphoribosyl Transferase Inhibitor, by Apoptosis-Mediated Death in Chronic Lymphocytic Leukemia Cells
Iris Gehrke et al.
CLINICAL CANCER RESEARCH (2014)
Nicotinamide phosphoribosyltransferase can affect metastatic activity and cell adhesive functions by regulating integrins in breast cancer
Antonio F. Santidrian et al.
DNA REPAIR (2014)
Nicotinamide Phosphoribosyltransferase Promotes Epithelial-to-Mesenchymal Transition as a Soluble Factor Independent of Its Enzymatic Activity
Debora Soncini et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Metabolomics Analysis of Metabolic Effects of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibition on Human Cancer Cells
Vladimir Tolstikov et al.
PLOS ONE (2014)
NAD+ depletion by APO866 in combination with radiation in a prostate cancer model, results from an in vitro and in vivo study
Shuraila F. Zerp et al.
RADIOTHERAPY AND ONCOLOGY (2014)
NAD+ and sirtuins in aging and disease
Shin-ichiro Imai et al.
TRENDS IN CELL BIOLOGY (2014)
NAMPT and NAPRT1: novel polymorphisms and distribution of variants between normal tissues and tumor samples
Sara Duarte-Pereira et al.
SCIENTIFIC REPORTS (2014)
Intracellular NAD+ depletion induces autophagic death in multiple myeloma cells
Michele Cea et al.
AUTOPHAGY (2013)
Intracellular NAD(H) levels control motility and invasion of glioma cells
Remco van Horssen et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2013)
Loss of NAPRT1 Expression by Tumor-Specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors
David S. Shames et al.
CLINICAL CANCER RESEARCH (2013)
Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Therapeutics: Rationales, Controversies, Clinical Experience
By Fabrizio Montecucco et al.
CURRENT DRUG TARGETS (2013)
NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity
Sathisha Upparahalli Venkateshaiah et al.
EXPERIMENTAL HEMATOLOGY (2013)
Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells
Basant Kumar Thakur et al.
INTERNATIONAL JOURNAL OF CANCER (2013)
De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients
David Akhavan et al.
CANCER DISCOVERY (2013)
Dependence of Tumor Cell Lines and Patient-Derived Tumors on the NAD Salvage Pathway Renders Them Sensitive to NAMPT Inhibition with GNE-618
Yang Xiao et al.
NEOPLASIA (2013)
Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition
Michele Cea et al.
BLOOD (2012)
Nampt/Visfatin/PBEF: A Functionally Multi-faceted Protein with a Pivotal Role in Malignant Tumors
He Jieyu et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells
Ilirjana Bajrami et al.
EMBO MOLECULAR MEDICINE (2012)
Anti-proliferation effect of APO866 on C6 glioblastoma cells by inhibiting nicotinamide phosphoribosyltransferase
Li-Yuan Zhang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2012)
Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity by Small Molecule GMX1778 Regulates Reactive Oxygen Species (ROS)-mediated Cytotoxicity in a p53-and Nicotinic Acid Phosphoribosyltransferase1 (NAPRT1)-dependent Manner
David Cerna et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Nicotinamide Phosphoribosyltransferase: A Potent Therapeutic Target in Non-small Cell Lung Cancer with Epidermal Growth Factor Receptor-Gene Mutation
Shunsuke Okumura et al.
JOURNAL OF THORACIC ONCOLOGY (2012)
Nicotinamide Phosphoribosyl Transferase (Nampt) Is Required for De Novo Lipogenesis in Tumor Cells
Sarah C. Bowlby et al.
PLOS ONE (2012)
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
Antje Menssen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Nampt is involved in DNA double-strand break repair
Bingtao Zhu et al.
CHINESE JOURNAL OF CANCER (2012)
The NAD metabolome - a key determinant of cancer cell biology
Alberto Chiarugi et al.
NATURE REVIEWS CANCER (2012)
Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas
Uffe Hogh Olesen et al.
APMIS (2011)
NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response
B. Wang et al.
ONCOGENE (2011)
Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil
Tie-Qiang Bi et al.
ONCOLOGY REPORTS (2011)
Quinolinate phosphoribosyl transferase, a key enzyme in de novo NAD+ synthesis, suppresses spontaneous cell death by inhibiting overproduction of active-caspase-3
Kazumi Ishidoh et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2010)
SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions
Tong Zhang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)
Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data
Anne von Heideman et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2010)
The Nicotinamide Phosphoribosyltransferase: A Molecular Link between Metabolism, Inflammation, and Cancer
Mara Galli et al.
CANCER RESEARCH (2010)
A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity
Huei-Jiun Yang et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2010)
Potent synergistic interaction between the Nampt inhibitor AP0866 and the apoptosis activator TRAIL in human leukemia cells
Gabriele Zoppoli et al.
EXPERIMENTAL HEMATOLOGY (2010)
A Preclinical Study on the Rescue of Normal Tissue by Nicotinic Acid in High-Dose Treatment with APO866, a Specific Nicotinamide Phosphoribosyltransferase Inhibitor
Uffe Hogh Olesen et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities
Georg T. Wondrak
ANTIOXIDANTS & REDOX SIGNALING (2009)
QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study
Nora Hinsch et al.
BMC CANCER (2009)
The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors
Mark Watson et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Dunyaporn Trachootham et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
A phase 1 trial of GMX1777: An inhibitor of nicotinamide phosphoribosyl transferase (NAMPRT)
M. J. Pishvaian et al.
JOURNAL OF CLINICAL ONCOLOGY (2008)
The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor
Kyle Holen et al.
INVESTIGATIONAL NEW DRUGS (2008)
NAD(+) and NADH in cellular functions and cell death
Weihai Ying
FRONTIERS IN BIOSCIENCE-LANDMARK (2006)
Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: An ECSG/EORTC study
A Ravaud et al.
EUROPEAN JOURNAL OF CANCER (2005)
Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD(+) into a nuclear signal
MY Kim et al.
GENES & DEVELOPMENT (2005)
Share Paper
