Journal
BIOTECHNOLOGY ADVANCES
Volume 33, Issue 6, Pages 830-841Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2015.04.006
Keywords
Metabolic engineering; Tricarboxylic acid (TCA) cycle; Citric acid; alpha-Ketoglutaric acid; Succinic acid; Fumaric acid; L-Malic acid; Oxaloacetate; C-4-dicarboxylic acid
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Funding
- 863 project [2014AA021201]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- 111 Project [111-2-06]
- Open Funding Project of the State Key Laboratory of Bioreactor Engineering
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Organic acids, which are chemically synthesized, are also natural intermediates in the metabolic pathways of microorganisms, among which the tricarboxylic acid (TCA) cycle is the most crucial route existing in almost all living organisms. Organic acids in the TCA cycle include citric acid, a-ketoglutaric acid, succinic acid, fumaric acid, L-malic acid, and oxaloacetate, which are building-block chemicals with wide applications and huge markets. In this review, we summarize the synthesis pathways of these organic acids and review recent advances in metabolic engineering strategies that enhance organic acid production. We also propose further improvements for the production of organic acids with systems and synthetic biology-guided metabolic engineering strategies. (C) 2015 Elsevier Inc. All rights reserved.
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