Journal
CELLS
Volume 9, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/cells9010082
Keywords
autophagy; mitochondria; calorie restriction; aging; metabolism; inflammation
Categories
Funding
- European Research Council [H2020-EU.1.1., ERC-2016-StG 715322-EndoMitTalk]
- Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III [PI16/188, PI19/855]
- Fondo Europeo de Desarrollo Regional (FEDER)
- Miguel Servet program from Instituto de Salud Carlos III [CPII19/00014]
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Mitochondrial metabolism and autophagy are two of the most metabolically active cellular processes, playing a crucial role in regulating organism longevity. In fact, both mitochondrial dysfunction or autophagy decline compromise cellular homeostasis and induce inflammation. Calorie restriction (CR) is the oldest strategy known to promote healthspan, and a plethora of CR mimetics have been used to emulate its beneficial effects. Herein, we discuss how CR and CR mimetics, by modulating mitochondrial metabolism or autophagic flux, prevent inflammatory processes, protect the intestinal barrier function, and dampen both inflammaging and neuroinflammation. We outline the effects of some compounds classically known as modulators of autophagy and mitochondrial function, such as NAD(+) precursors, metformin, spermidine, rapamycin, and resveratrol, on the control of the inflammatory cascade and how these anti-inflammatory properties could be involved in their ability to increase resilience to age-associated diseases.
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