Journal
CELLS
Volume 8, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/cells8121634
Keywords
post-transcriptional regulation; RNA alteration; microRNA; competing endogenous RNA; RNA-binding protein; cancer; transcriptomic equilibrium
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Funding
- National Research Foundation Singapore
- Singapore Ministry of Education under its Research Centres of Excellence initiative
- RNA Biology Center at the Cancer Science Institute of Singapore, NUS under the Singapore Ministry of Education's AcRF [MOE2014-T3-1-006]
- Singapore National Research Foundation
- National University of Singapore
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Post-transcriptional regulation plays a key role in modulating gene expression, and the perturbation of transcriptomic equilibrium has been shown to drive the development of multiple diseases including cancer. Recent studies have revealed the existence of multiple post-transcriptional processes that coordinatively regulate the expression and function of each RNA transcript. In this review, we summarize the latest research describing various mechanisms by which small alterations in RNA processing or function can potentially reshape the transcriptomic landscape, and the impact that this may have on cancer development.
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