Journal
CARBOHYDRATE POLYMERS
Volume 136, Issue -, Pages 764-771Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.09.105
Keywords
Biomaterials; Nerve regeneration; Chitosan; Hydrogel; Electrodeposition
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Funding
- Faculty of Process and Environmental Engineering at Lodz University of Technology
- Foundation for Polish Science [73/UD/SKILLS/2014]
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A new method for fabrication of chitosan-based hydrogel implants intended for peripheral nervous tissue regeneration was developed. The method is based on an electrodeposition phenomenon from a solution of chitosan and organic acid. In order to increase the mechanical strength of the implant, the solution was enriched with hydroxyapatite. Hydroxyapatite served as a source of calcium ions too. The influence of the concentration of the polymer and the additive on chemical, mechanical as well as biological properties of the obtained implant was evaluated. The study showed great dependence of the initial solution composition mainly on the physicochemical properties of the resulting structure. Basic in vitro cytotoxic and pro-inflammatory assays showed biocompatibility of manufactured implants, therefore, animal experimentations may be considered. (C) 2015 Elsevier Ltd. All rights reserved.
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