Journal
BIOTECHNOLOGY ADVANCES
Volume 33, Issue 8, Pages 1522-1546Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2015.07.010
Keywords
Yarrowia lipolytica; Characteristics; Physiology; Metabolism; Applications
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Funding
- National Science Foundation for Distinguished Young Scholars of China [21225626]
- National Basic Research Program of China [2011CBA00800]
- National Natural Science Foundation of China [21376002, 21476111]
- Jiangsu Province Natural Science Foundation of China [BK20131405]
- National High-Tech R&D Program of China [2014AA021701, 2014AA021703]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Non-conventional yeasts have attracted increasing interest due to their biochemical characteristics and potential applications. Yarrowia lipolytica is a non-conventional yeast with specific characteristics and physiology. The potential physiological and metabolic capabilities of Y. lipolytica, which can assimilate many different carbon Sources, including typical hydrophilic and hydrophobic materials, are reviewed in this paper. Concerning the uptake and metabolism substrates, this review focuses particularly on low-cost raw materials, such as glycerol. Moreover, this review presents the results of safety studies of Y. lipolytica. Finally, the wide applications of Y. lipolytica, such as functional enzyme production, metabolite synthesis and environmental bioremediation, are reviewed in this paper. Recently, with the development of system biology and synthetic biology, it was concluded that these technologies will provide new opportunities for potential applications of Y. lipolytica in the future. (C) 2015 Elsevier Inc All rights reserved.
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