Journal
CANCERS
Volume 12, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/cancers12010184
Keywords
vimentin; EMT; invasion; mechanotransduction; cell adhesion; cancer treatment; cancer drugs; amoeboid; mesenchymal
Categories
Funding
- Czech Science Foundation of the Ministry of Education, Youth, and Sports of the Czech Republic within National Sustainability Program II (Project BIOCEV-FAR) [18-15684J, 19-03932S, LQ1604]
- project 'Center for Tumor Ecology-Research of the Cancer Microenvironment Supporting Cancer Growth and Spread' - Operational Programme Research, Development, and Education [CZ.02.1.01/0.0/0.0/16_019/0000785]
- Grant Agency of the Ministry of Health of the Czech Republic [17-31538A]
- COST Action [CA15214-EuroCellNet (LTC17063)]
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Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of structurally related proteins showing distinct expression patterns in tissues and cell types. Changes in the expression patterns of intermediate filaments are often associated with cancer progression; in particular with phenotypes leading to increased cellular migration and invasion. In this review we will describe the role of vimentin intermediate filaments in cancer cell migration, cell adhesion structures, and metastasis formation. The potential for targeting vimentin in cancer treatment and the development of drugs targeting vimentin will be reviewed.
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