Journal
CARBOHYDRATE POLYMERS
Volume 150, Issue -, Pages 74-81Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.05.008
Keywords
Polysaccharide; Dyslipidemia; Bile acids; UPLC-MS; Nuclear receptors
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Funding
- Natural Science Foundation of China [81173516]
- Doctoral Program of Higher Education [20133107120004, 20133107110005]
- Shanghai Education Commission Leading Academic Discipline Project [zyx-cxyj-016]
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Hyperlipidemia is a chronic metabolic disorder with systemic complications that is prevalent worldwide. MDG-1, a water-soluble p-o-fructan polysaccharide from Ophiopogon japonicas has potent hypolipidemic and weight-control effects. The present study aimed to investigate the effects of MDG-1 on lipid metabolic disorders in diet-induced obese mice based on the metabolic profile of bile acids. C57BL/6 mice were treated with a low-fat diet, high-fat diet or high fat mixed with 1%. (w/w) MDG-1 diet for 12 weeks. The results showed that MDG-1 inhibited body weight gain and lowered serum and liver total cholesterol contents in obese mice. In addition, MDG-1 could adsorb bile acids in the gut lumen and reduce their reabsorption, thus promoting cholesterol catabolism. Furthermore, MDG-1 inhibited the expression of the farnesoid X receptor, but activated the liver X receptor. Our findings shed new light on the mechanism of MDG-1 in the control of lipids. (C) 2016 Elsevier Ltd. All rights reserved.
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