Journal
SCIENCE ADVANCES
Volume 6, Issue 2, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aax4001
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Funding
- CNRS, the University of Montpellier
- European Research Council [232947, 788972]
- European Union [676556]
- Agence Nationale de la Recherche [ANR-15-CE12-006-01]
- Fondation pour la Recherche Medicale [DEI20151234396]
- French National Cancer Institute (INCA) [PLBIO16-222]
- Laboratory of Excellence EpiGenMed [ANR-10-LABX-12]
- Fondation ARC pour la Recherche sur le Cancer [PJA 20171206301]
- Laboratory of Excellence EpiGenMed
- Fondation ARC pour la Recherche sur le Cancer
- French Ministry of Higher Education and Research
- la Ligue nationale contre le cancer
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Polycomb repressive complexes 1 and 2 have been historically described as transcriptional repressors, but recent reports suggest that PRC1 might also support activation, although the underlying mechanisms remain elusive. Here, we show that stage-specific PRC1 binding at a subset of active promoters and enhancers during Drosophila development coincides with the formation of three-dimensional (3D) loops, an increase in expression during development and repression in PRC1 mutants. Dissection of the dachshund locus indicates that PRC1-anchored loops are versatile architectural platforms that persist when surrounding genes are transcriptionally active and fine-tune their expression. The analysis of RING1B binding profiles and 3D contacts during neural differentiation in mice suggests that this role is conserved in mammals.
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