Journal
CHEM
Volume 6, Issue 4, Pages 919-932Publisher
CELL PRESS
DOI: 10.1016/j.chempr.2020.01.009
Keywords
-
Categories
Funding
- Hong Kong Special Administrative Region General Research Funding [CUHK14315716, CUHK14304918]
- Chinese University of Hong Kong [4053203, 4053327]
- Innovation and Technology Commission [GHP/004/16GD]
- Chinese University of Hong Kong Research Fellowship Scheme
Ask authors/readers for more resources
Privileged chiral catalyst scaffolds are highly useful in chemical synthesis such as drug preparation. Substituted phenol ligands are among the most frequently used scaffolds. However, the preparation of chiral phenol ligands commonly involves tedious synthetic procedures. Herein, we describe a facile strategy to prepare potent chiral bisphenols (BPOLs) through the desymmetrizing asymmetric ortho-halogenation. Both theoretical and experimental studies were conducted in order to shed light on the mechanistic picture The halogen handles in the BPOL products are manipulated to yield unsymmetrical chiral BPOL ligands, which are potential privileged catalyst scaffolds and have been applied in other asymmetric catalytic reactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available