Journal
ACS SENSORS
Volume 5, Issue 3, Pages 601-619Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.9b02039
Keywords
molecular imprinting; surface-enhanced Raman scattering; sensor; molecularly imprinted polymers; construction strategy; applications; challenges; perspectives
Funding
- Youth Innovation Promotion Association CAS [2017256]
- National Natural Science Foundation of China [21876199, 21804010, 41776110, 81573393, 21976209]
- Instrument Developing Project of the Chinese Academy of Sciences [YZ201662]
- Science and Technology Development Plan of Shandong Province of China [2019GSF108047]
- Technical Innovation Project of Instrument Function Development of the Chinese Academy of Sciences
- Chinese Academy of Sciences President's International Fellowship Initiative [2019PC0050]
- Taishan Scholar Project [ts20190962]
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Molecularly imprinted polymers (MIPs) receive extensive interest, owing to their structure predictability, recognition specificity, and application universality as well as robustness, simplicity, and inexpensiveness. Surface-enhanced Raman scattering (SERS) is regarded as an ideal optical detection candidate for its unique features of fingerprint recognition, nondestructive property, high sensitivity, and rapidity. Accordingly, MIP based SERS (MIP-SERS) sensors have attracted significant research interest for versatile applications especially in the field of chemo- and bioanalysis, showing excellent identification and detection performances. Herein, we comprehensively review the recent advances in MIP-SERS sensors construction and applications, including sensing principles and signal enhancement mechanisms, focusing on novel construction strategies and representative applications. First, the basic structure of the MIP-SERS sensors is briefly outlined. Second, novel imprinting strategies are highlighted, mainly including multifunctional monomer imprinting, dummy template imprinting, living/controlled radical polymerization, and stimuli-responsive imprinting. Third, typical application of MIP-SERS sensors in chemo/bioanalysis is summarized from both small and macromolecular aspects. Lastly, the challenges and perspectives of the MIP-SERS sensors are proposed, orienting sensitivity improvement and application expanding.
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