Journal
BIOTECHNOLOGY ADVANCES
Volume 33, Issue 5, Pages 526-546Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2015.01.007
Keywords
Hydratase; Hydro-lyase; Water addition; Syn-addition; Anti-addition; Michael addition; Stereochemistly; Alcohol
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Funding
- China Scholarship Council-Delft University of Technology Joint Program
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Water addition to carbon-carbon double bonds using hydratases is attracting great interest in biochemistry. Most of the known hydratases are involved in primary metabolism and to a lesser extent in secondary metabolism. New hydratases have recently been added to the toolbox, both from natural sources or artificial metalloenzymes. In order to comprehensively understand how the hydratases are able to catalyse the water addition to carbon-carbon double bonds, this review will highlight the mechanistic and stereochemical studies of the enzymatic water addition to carbon-carbon double bonds, focusing on the syn/anti-addition and stereochemistry of the reaction. (C) 2015 Elsevier Inc. All rights reserved.
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