Journal
FRONTIERS IN PSYCHIATRY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2019.00872
Keywords
human aggression; adrenocorticotropic hormone; oxytocin; vasopressin; autoantibodies; hypothalamic-pituitary-adrenal axis; cortisol; epitopes
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Funding
- Transversal Microbiota Program of Inserm, France
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Adrenocorticotropic hormone together with arginine vasopressin and oxytocin, the neuropeptides regulating the stress response and the hypothalamic-pituitary-adrenal axis activity, are known to modulate aggressive behavior. The functional role of the adrenocorticotropic hormone immunoglobulin G autoantibodies in peptidergic signaling and motivated behavior, including aggression, has been shown in experimental and in vitro models. This review summarizes some experimental data implicating autoantibodies reactive with stress-related peptides in aggressive behavior.
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