Journal
CANCER MANAGEMENT AND RESEARCH
Volume 12, Issue -, Pages 1069-1078Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S238306
Keywords
cancer chemotherapy; mucositis; Hangeshashinto; TJ-14; Kampo medicine; traditional Japanese medicine; oral cancer
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Purpose: Hangeshashinto (TJ-14), a Kampo medicine comprising seven types of herbs, has been used in Japan to alleviate the side effects associated with anticancer drug treatments. However, the pharmacological effects of this medicine currently remain unclear. The present study aimed to demonstrate the efficacy of TJ-14 against anticancer drug-induced stomatitis, the pain associated with which may have a negative impact on mastication and swallowing. Methods: Mucositis was induced in Sprague-Dawley rats by cancer chemotherapy. Changes in body weight, stomatitis grades, histopathological scores, and oral bacterial counts were examined among TJ-14-treated, saline-treated, and Control (no treatment) rats. In vitro studies, including cell proliferation and wound healing assays, using epidermal keratinocyte and fibroblast cell lines were conducted. Results: The local application of TJ-14 exerted strong antibacterial effects and attenuated oral chemotherapy-induced stomatitis in rats. TJ-14 also increased the viability and invasion of epidermal keratinocytes and fibroblasts. Conclusion: The present results demonstrated the potential of TJ-14 to attenuate chemotherapy-induced stomatitis.
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