Journal
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
Volume 7, Issue 2, Pages 239-244Publisher
WILEY
DOI: 10.1002/acn3.50974
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Funding
- Wilhelm Sander Foundation [2011.113.1, 2011.113.2]
- German Research Council through the Munich Cluster for Systems Neurology [SyNergy EXC 2145, 390857198]
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The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with idiopathic gamma-aminobutyric-acid-A receptor (GABA(A)-R) encephalitis by next-generation sequencing and single-cell analyses. We identified a CD8+ T cell clone that was strongly expanded in the cerebrospinal fluid and in the hippocampus but not in the operculo-insular cortex. By contrast, CD4+ T cells were polyclonal in these tissues. Such a strong clonal expansion suggests that CD8+ T cells may play a significant role in the pathogenesis.
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