Journal
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
Volume 7, Issue 1, Pages 132-138Publisher
WILEY
DOI: 10.1002/acn3.50971
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Funding
- Dutch National Epilepsy Foundation [2017-10]
- EU [6026337]
- EU IAPP Program BRAINPATH [612360]
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Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events - the electrophysiological correlate of the migraine aura - in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V-mutated alpha 1 subunits in voltage-gated Na(V)1.1 sodium channels (Scn1a(L263V)). CSDs consistently propagated from visual to motor cortex, recapitulating what has been shown in patients with migraine with aura. This model may be valuable for the preclinical study of migraine with aura and other diseases in which spreading depolarization is a prominent feature.
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