Related references
Note: Only part of the references are listed.Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
Masha G. Savelieff et al.
CHEMICAL REVIEWS (2019)
NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry
Enzo Alessio et al.
MOLECULES (2019)
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes
Ross Nortley et al.
SCIENCE (2019)
A vicious cycle of β amyloid-dependent neuronal hyperactivation
Benedikt Zott et al.
SCIENCE (2019)
2019 Alzheimer's disease facts and figures
Joseph Gaugler et al.
ALZHEIMERS & DEMENTIA (2019)
A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation
Luiza M. F. Gomes et al.
CHEMICAL SCIENCE (2019)
Amyloid β oligomers (AβOs) in Alzheimer's disease
Barbara Mroczko et al.
JOURNAL OF NEURAL TRANSMISSION (2018)
The NAMI A - human ferritin system: a biophysical characterization
Silvia Ciambellotti et al.
DALTON TRANSACTIONS (2018)
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
Claudio Soto et al.
NATURE NEUROSCIENCE (2018)
A new era for understanding amyloid structures and disease
Matthew G. Iadanza et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition
Evgeny P. Barykin et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective
Enzo Alessio
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2017)
Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides
Jeffrey S. Derrick et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Challenges in studying the structures of metal-amyloid oligomers related to type 2 diabetes, Parkinson's disease, and Alzheimer's disease
Vered Wineman-Fisher et al.
COORDINATION CHEMISTRY REVIEWS (2016)
Biophysical Comparison of Soluble Amyloid-β(1-42) Protofibrils, Oligomers, and Protofilaments
Michael R. Nichols et al.
BIOCHEMISTRY (2015)
Neurodegenerative diseases and therapeutic strategies using iron chelators
Roberta J. Ward et al.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2015)
Modulation of the Aβ peptide aggregation pathway by KP1019 limits Aβ-associated neurotoxicity
Michael R. Jones et al.
METALLOMICS (2015)
Methionine oxidation of amyloid peptides by peroxovanadium complexes: inhibition of fibril formation through a distinct mechanism
Lei He et al.
METALLOMICS (2015)
Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy
Suzanne Leijen et al.
INVESTIGATIONAL NEW DRUGS (2015)
Modulation of Amyloid-β Aggregation by Histidine-Coordinating Cobalt(III) Schiff Base Complexes
Marie C. Heffern et al.
CHEMBIOCHEM (2014)
Ruthenium metalation of proteins: the X-ray structure of the complex formed between NAMI-A and hen egg white lysozyme
Luigi Messori et al.
DALTON TRANSACTIONS (2014)
8-Hydroxyquinoline Schiff-base compounds as antioxidants and modulators of copper-mediated Aβ peptide aggregation
Luiza M. F. Gomes et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2014)
Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer's Disease
Sanghyun Lee et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function
Su Ling Leong et al.
METALLOMICS (2014)
NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application
Robert Trondl et al.
CHEMICAL SCIENCE (2014)
Effect of Metals on Kinetic Pathways of Amyloid-β Aggregation
Francis Hane et al.
BIOMOLECULES (2014)
Untangling Amyloid-β, Tau, and Metals in Alzheimer's Disease
MG Savelieff et al.
ACS CHEMICAL BIOLOGY (2013)
Development of a Platinum Complex as an anti-Amyloid Agent for the Therapy of Alzheimer's Disease
Vijaya B. Kenche et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Stability of early-stage amyloid-β(1-42) aggregation species
Kelley A. Coalier et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2013)
Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide
Victor A. Streltsov et al.
CHEMICAL COMMUNICATIONS (2013)
Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease
Fabrice Collin et al.
CHEMICAL COMMUNICATIONS (2013)
Increasing the Bioavailability of RuIII Anticancer Complexes through Hydrophobic Albumin Interactions
Michael I. Webb et al.
CHEMISTRY-A EUROPEAN JOURNAL (2013)
Interaction of Anticancer Ruthenium Compounds with Proteins: High-Resolution X-ray Structures and Raman Microscopy Studies of the Adduct between Hen Egg White Lysozyme and AziRu
Alessandro Vergara et al.
INORGANIC CHEMISTRY (2013)
Investigating the Ruthenium Metalation of Proteins: X-ray Structure and Raman Microspectroscopy of the Complex between RNase A and AziRu
Alessandro Vergara et al.
INORGANIC CHEMISTRY (2013)
Metals, Membranes, and Amyloid-beta Oligomers: Key Pieces in the Alzheimer's Disease Puzzle?
Andrew D. Watt et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein (vol 79, pg 887, 2013)
Ji Won Um et al.
NEURON (2013)
Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex
Luigi Messori et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
Therapeutic Redistribution of Metal Ions To Treat Alzheimer's Disease
Peter J. Crouch et al.
ACCOUNTS OF CHEMICAL RESEARCH (2012)
Facile Methodology for Monitoring Amyloid-β Fibrillization
Nathan P. Cook et al.
ACS CHEMICAL NEUROSCIENCE (2012)
Bioinorganic Chemistry of Alzheimer's Disease
Kasper P. Kepp
CHEMICAL REVIEWS (2012)
Misfolded proteins in Alzheimer's disease and type II diabetes
Alaina S. DeToma et al.
CHEMICAL SOCIETY REVIEWS (2012)
Diagnostic imaging of Alzheimer's disease with copper and technetium complexes
James L. Hickey et al.
COORDINATION CHEMISTRY REVIEWS (2012)
Metal binding sites in amyloid oligomers: Complexes and mechanisms
Yifat Miller et al.
COORDINATION CHEMISTRY REVIEWS (2012)
The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases
Cristina Rodriguez-Rodriguez et al.
COORDINATION CHEMISTRY REVIEWS (2012)
Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide
Isabelle Sasaki et al.
DALTON TRANSACTIONS (2012)
Histidine-rich branched peptides as Cu(II) and Zn(II) chelators with potential therapeutic application in Alzheimer's disease
Andrea Lakatos et al.
DALTON TRANSACTIONS (2012)
Pyridine Analogues of the Antimetastatic Ru(III) Complex NAMI-A Targeting Non-Covalent Interactions with Albumin
Michael I. Webb et al.
INORGANIC CHEMISTRY (2012)
Reactivity of Diphenylpropynone Derivatives Toward Metal-Associated Amyloid-β Species
Amit S. Pithadia et al.
INORGANIC CHEMISTRY (2012)
Hexafluoroisopropanol induces self-assembly of ß-amyloid peptides into highly ordered nanostructures
Sanjai Kumar Pachahara et al.
JOURNAL OF PEPTIDE SCIENCE (2012)
Dual-function triazole-pyridine derivatives as inhibitors of metal-induced amyloid-beta aggregation
Michael R. Jones et al.
METALLOMICS (2012)
NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer
Robert Trondl et al.
BMC Pharmacology & Toxicology (2012)
Metal ions, Alzheimer's disease and chelation therapy
Ana Budimir
ACTA PHARMACEUTICA (2011)
Copper(II) Coordination to Amyloid beta: Murine versus Human Peptide
Helene Eury et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Iron(II) Binding to Amyloid-β, the Alzheimer's Peptide
Fatima Bousejra-ElGarah et al.
INORGANIC CHEMISTRY (2011)
Pharmacokinetic study of sodium trans[tetrachlorobis(1H-indazole)-ruthenate (III)]/-indazole hydrochloride (1:1.1) (FFC14A) in patients with solid tumors
M.M. Henke et al.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS (2011)
Molecular-Level Examination of Cu2+ Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer's β by Solid-State NMR Spectroscopy
Sudhakar Parthasarathy et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Resolving controversies on the path to Alzheimer's therapeutics (vol 17, pg 1060, 2011)
Dennis J. Selkoe
NATURE MEDICINE (2011)
The X-ray Structure of the Adduct between NAMI-A and Carbonic Anhydrase Provides Insights into the Reactivity of this Metallodrug with Proteins
Angela Casini et al.
CHEMMEDCHEM (2010)
fac-{Ru(Co)3}2+ Selectively Targets the Histidine Residues of the β-Amyloid Peptide 1-28. Implications for New Alzheimer's Disease Treatments Based on Ruthenium Complexes
Daniela Valensin et al.
INORGANIC CHEMISTRY (2010)
Alzheimer's Disease: A General Introduction and Pathomechanism
Verena H. Finder
JOURNAL OF ALZHEIMERS DISEASE (2010)
Alzheimer's disease: strategies for disease modification
Martin Citron
NATURE REVIEWS DRUG DISCOVERY (2010)
MECHANISMS OF DISEASE Alzheimer's Disease
Henry W. Querfurth et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Zinc ions promote Alzheimer Aβ aggregation via population shift of polymorphic states
Yifat Miller et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Alzheimer's Disease: From Pathology to Therapeutic Approaches
Roland Jakob-Roetne et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Metal binding to alpha-synuclein peptides and its contribution to toxicity
David R. Brown
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Amyloid deposits Protection against toxic protein species?
Sebastian Treusch et al.
CELL CYCLE (2009)
Comparative Study of Inhibition at Multiple Stages of Amyloid-β Self-Assembly Provides Mechanistic Insight
Timothy J. Davis et al.
MOLECULAR PHARMACOLOGY (2009)
KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients
Christian G. Hartinger et al.
CHEMISTRY & BIODIVERSITY (2008)
Reactivity of histidine and lysine side-chains with diethylpyrocarbonate -: A method to identify surface exposed residues in proteins
Ales Hnizda et al.
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS (2008)
Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes SIGNIFICANCE FOR EFFECTIVENESS AS ANTICANCER DRUGS
Jan Reedijk
PLATINUM METALS REVIEW (2008)
Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer's disease
Kevin J. Barnham et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Redox chemistry of copper-amyloid-β:: The generation of hydroxyl radical in the presence of ascorbate is linked to redox-potentials and aggregation state
Luc Guilloreau et al.
CHEMBIOCHEM (2007)
Synthesis, characterization, and metal coordinating ability of multifunctional carbohydrate-containing compounds for Alzheimer's therapy
Tim Storr et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide
Christian Haass et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Ruthenium complexes can target determinants of tumour malignancy
A. Bergamo et al.
DALTON TRANSACTIONS (2007)
Cleavage agents for soluble oligomers of amyloid beta peptides
Junghun Suh et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
A beta Oligomers - a decade of discovery
Dominic M. Walsh et al.
JOURNAL OF NEUROCHEMISTRY (2007)
100 years and counting: Prospects for defeating Alzheimer's disease
Erik D. Roberson et al.
SCIENCE (2006)
A specific amyloid-β protein assembly in the brain impairs memory
S Lesné et al.
NATURE (2006)
Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis)
Elena Gaggelli et al.
CHEMICAL REVIEWS (2006)
NMR mapping of copper binding sites in alpha-synuclein
YH Sung et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2006)
Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid β-peptide by NMR
SG Yao et al.
JOURNAL OF PEPTIDE SCIENCE (2004)
Ruthenium antimetastatic agents
E Alessio et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2004)
Alzheimer's disease-affected brain:: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss
YS Gong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
An autocatalytic reaction, as a model for the kinetics of the aggregation of beta-amyloid
R Sabate et al.
BIOPOLYMERS (2003)
Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus
HW Wang et al.
BRAIN RESEARCH (2002)
Alzheimer's disease amyloid-β binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
CC Curtain et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)