Journal
MATERIALS & DESIGN
Volume 188, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2019.108432
Keywords
DOPA-bFGF; DOPA-PonG1; PLGA; Patterned; Nanofibrous films; Skin tissue engineering
Categories
Funding
- Jilin Province [SXGJQY2017-1, SXGJSF2017-2]
- Jilin University [SXGJQY2017-1, SXGJSF2017-2]
- Jilin Provincial Science & Technology Department [20190303039SF]
- Programfor JLU Science and Technology Innovative Research Team [2017TD-04]
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Combining biodegradable materials with bioactive factors for skin wound healing has been receiving significant attention. This study was inspired by the adhesion mechanism of a marine organism, the mussel. 3,4-Dihydroxyphenylalanine (DOPA) was introduced to basic fibroblast growth factor (bFGF) and poneridn G1 (PonG1) using tyrosine hydroxylation, which are expected to have strong binding affinities to the surfaces of materials. DOPA-bFGF and DOPA-PonG1 were applied for the surface modification of patterned poly(lactic-co-glycolic acid) (PLGA) electrospun nanofibrous films for skin wound healing. The DOPA-bFGF- and DOPA-PonG1-modified patterned PLGA nanofibrous films were analysed using scanning electron microscopy (SEM), contact angle, and materials testing machine. Then, the immobilization efficiencies and antibacterial abilities of the different films were examined. The results show that the DOPA-bFGF- and DOPA-PonG1-modified PLGA nanofibrous films exhibited bionic performance, improved tensile strength, and hydrophilicity. DOPA-bFGF and DOPA-PonG1 exhibited stronger binding abilities to films compared with bFGF and PonGl. DOPA-bFGF and DOPA-PonG1 films can significantly promote BALB/c 3T3 cell attachment, proliferation and tissue repairrelated gene expression. In vivo experiments indicated that DOPA-PonG1/DOPA-bFGF@PLGA nanofibrous films shortened the wound healing time, accelerated epithelialization and promoted skin remodelling. (C) 2019 The Authors. Published by Elsevier Ltd.
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