Journal
ACS CENTRAL SCIENCE
Volume 6, Issue 3, Pages 404-412Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscentsci.9b01174
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Funding
- Swiss National Science Foundation [315230_173243]
- Foundation Pierre Mercier pour la science
- ISREC Foundation
- Novartis Foundation for medical-biological Research [17A058]
- Swiss Cancer League [KFS-4600-08-2018]
- Ecole polytechnique federale de Lausanne (EPFL)
- European Commission under its framework programme Horizon 2020 [754462]
- Chinese Scholarship Council (CSC) [201700260266]
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A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigens and adjuvants together with a tracelessly responsive linker-monomer. Peptide-based neoantigens with diverse sequences and structures could be copolymerized with molecular adjuvants to form PNEs of high loading capacity for vaccine delivery without adding any carriers. The redox-responsive PNEs with controlled molecular weights and sizes efficiently targeted and accumulated in draining lymph nodes and greatly promoted the antigen capture and cross-presentation by professional antigen presenting cells. Mice immunized with PNEs showed markedly enhanced antigen-specific T cell response and the protective immunity against the tumor cell challenge.
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