Journal
JOURNAL OF STROKE
Volume 22, Issue 1, Pages 64-75Publisher
KOREAN STROKE SOC
DOI: 10.5853/jos.2019.03440
Keywords
Intracranial thrombus; Histology; Stroke; Thrombectomy
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2018R1A2A3074996]
- Yonsei University College of Medicine [6-2018-0185]
Ask authors/readers for more resources
Recent advances in endovascular thrombectomy have enabled the histopathologic analysis of fresh thrombi in patients with acute stroke. Histologic analysis has shown that the thrombus composition is very heterogeneous between patients. However, the distribution pattern of each thrombus component often differs between patients with cardiac thrombi and those with arterial thrombi, and the efficacy of endovascular thrombectomy is different according to the thrombus composition. Furthermore, the thrombus age is related to the efficacy of reperfusion therapy. Recent studies have shown that neutrophils and neutrophil extracellular traps contribute to thrombus formation and resistance to reperfusion therapy. Histologic features of thrombi in patients with stroke may provide some clues to stroke etiology, which is helpful for determining the strategy of stroke prevention. Research on thrombus may also be helpful for improving reperfusion therapy, including the development of new thrombolytic agents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available