Journal
INFECTIOUS DISEASES
Volume 52, Issue 6, Pages 419-422Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/23744235.2020.1729403
Keywords
Coronavirus; encephalitis; next generation sequencing; brain biopsy
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A child with pre-B acute lymphoblastic leukaemia (ALL) developed fatal encephalitis associated with human coronavirus OC43 (HCoV-OC43). During chemotherapy the child had a persistent HCoV-OC43 respiratory infection and later developed progressive encephalitis. Cerebrospinal fluid was negative for pathogens including HCoV-OC43, but a brain biopsy was HCoV-OC43-positive by metagenomic next-generation sequencing.
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