Journal
FRONTIERS IN IMMUNOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.00282
Keywords
gut microbiota; innate immunity; innate lymphoid cells; rheumatoid arthritis; spondyloarthritis; systemic lupus erythematosus
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Funding
- National Natural Science Foundation of China [81788101, 81630044, 81601432, 81550023, 81771763, 91542000, 31330027, 91642207]
- Chinese Academy of Medical Science Innovation Fund for Medical Sciences [CIFMS2016-12M-1003, 2017-12M-1-008, 2017-I2M-3-011, 2016-12M-1-008]
- National Key Research and Development Program: Precise Medical Research [2016YFC0903900]
- Ministry of Science and Technology of China [2015CB943200]
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The emerging concept of microbiota contributing to local mucosal homeostasis has fueled investigation into its specific role in immunology. Gut microbiota is mostly responsible for maintaining the balance between host defense and immune tolerance. Dysbiosis of gut microbiota has been shown to be related to various alterations of the immune system. This review focuses on the reciprocal relationship between gut microbiota and innate immunity compartment, with emphasis on gut-associated lymphoid tissue, innate lymphoid cells, and phagocytes. From a clinical perspective, the review gives a possible explanation of how the gut microbiota-innate immunity axis might contribute to the pathogenesis of autoimmune diseases like rheumatoid arthritis, spondyloarthritis, and systemic lupus erythematosus.
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