Journal
FRONTIERS IN IMMUNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.03130
Keywords
neutrophils; Cre-recombinase; diphtheria toxin; mouse models; depletion; Gfi-1; NETosis
Categories
Funding
- Jeunes Chercheuses/Jeunes Chercheurs grant from the Agence National de la Recherche [ANR-16-CE15-0012]
- ATIP-Avenir program
- Agence Nationale de la Recherche (ANR) [ANR-16-CE15-0012] Funding Source: Agence Nationale de la Recherche (ANR)
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Neutrophils are the most abundant leukocytes in human blood and critical actors of the immune system. Many neutrophil functions and facets of their activity in vivo were revealed by studying genetically modified mice or by tracking fluorescent neutrophils in animals using imaging approaches. Assessing the roles of neutrophils can be challenging, especially when exact molecular pathways are questioned or disease states are interrogated that alter normal neutrophil homeostasis. This review discusses the main in vivo models for the study of neutrophils, their advantages and limitations. The side-by-side comparison underlines the necessity to carefully choose the right model(s) to answer a given scientific question, and exhibit caveats that need to be taken into account when designing experimental procedures. Collectively, this review suggests that at least two models should be employed to legitimately conclude on neutrophil functions.
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