Journal
FRONTIERS IN IMMUNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.02884
Keywords
von Willebrand factor; platelet glycoprotein Ib alpha; thromboinflammation; ischemic stroke; ADAMTS13
Categories
Funding
- Fonds voor Wetenschappelijk Onderzoek Vlaanderen (FWO) [12U7818N]
- Fond voor Wetenschappelijk Onderzoek Vlaanderen [G.0A86.13, 1509216N, G.078517N]
- KU Leuven [OT/14/099]
- Queen Elisabeth Medical Foundation
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von Willebrand factor (VWF) and platelets are key mediators of normal hemostasis. At sites of vascular injury, VWF recruits platelets via binding to the platelet receptor glycoprotein Ib alpha (GPIb alpha). Over the past decades, it has become clear that many hemostatic factors, including VWF and platelets, are also involved in inflammatory processes, forming intriguing links between hemostasis, thrombosis, and inflammation. The so-called thrombo-inflammatory nature of the VWF-platelet axis becomes increasingly recognized in different cardiovascular pathologies, making it a potential therapeutic target to interfere with both thrombosis and inflammation. In this review, we discuss the current evidence for the thrombo-inflammatory activity of VWF with a focus on the VWF-GPIb alpha axis and discuss its implications in the setting of ischemic stroke.
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