Journal
FRONTIERS IN IMMUNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.02918
Keywords
T follicular helper (T-FH) cell; interleukin-21 (IL-21); T follicular regulatory (T-FR) cell; asthma; immunotherapy
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Funding
- Six Talent Peaks Project in Jiangsu Province [2017-WSN-186]
- Jiangsu Province 333 Project [BRA2019152]
- Youth Science Funds of Shandong Academy of Sciences [2018QN003]
- National Natural Science Foundation of China [81600692, 81970759]
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For many decades, T helper 2 (T(H)2) cells have been considered to predominantly regulate the pathogenic manifestations of allergic asthma, such as IgE-mediated sensitization, airway hyperresponsiveness, and eosinophil infiltration. However, recent discoveries have significantly shifted our understanding of asthma from a simple T(H)2 cell-dependent disease to a heterogeneous disease regulated by multiple T cell subsets, including T follicular helper (T-FH) cells. T-FH cells, which are a specialized cell population that provides help to B cells, have attracted intensive attention in the past decade because of their crucial role in regulating antibody response in a broad range of diseases. In particular, T-FH cells are essential for IgE antibody class-switching. In this review, we summarize the recent progress regarding the role of T-FH cells and their signature cytokine interleukin (IL)-21 in asthma from mouse studies and clinical reports. We further discuss future therapeutic strategies to treat asthma by targeting T-FH cells and IL-21.
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