Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2019.00316
Keywords
snRNA-Seq; scRNA-Seq; adult stria vascularis; regulons; hearing; EP
Categories
Funding
- Intramural Research Program of the NIH, NIDCD [ZIA DC000088, ZIC DC000086]
- NIH
- Doris Duke Charitable Foundation (DDCF) [2014194]
- American Association for Dental Research
- Colgate-Palmolive Company
- Genentech
- Elsevier
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The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is necessary for proper hair cell mechanotransduction and hearing. While channels belonging to SV cell types are known to play crucial roles in EP generation, relatively little is known about gene regulatory networks that underlie the ability of the SV to generate and maintain the EP. Using single cell and single nucleus RNA-sequencing, we identify and validate known and rare cell populations in the SV. Furthermore, we establish a basis for understanding molecular mechanisms underlying SV function by identifying potential gene regulatory networks as well as druggable gene targets. Finally, we associate known deafness genes with adult SV cell types. This work establishes a basis for dissecting the genetic mechanisms underlying the role of the SV in hearing and will serve as a basis for designing therapeutic approaches to hearing loss related to SV dysfunction.
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